Concepedia

Aged Microglia

Aged Microglia is a pathological phenotype of central nervous system-resident immune cells characterized by a senescence-associated secretory profile, dystrophic morphology, and impaired phagocytic and surveillance functions that contribute to neuroinflammation and neuronal dysfunction in the aging brain.

303

Publications

39.7K

Citations

2.1K

Authors

631

Institutions

Publications per year

2017–2026

172

Parents

Publications

303

Local self-renewal can sustain CNS microglia maintenance and function throughout adult life

Bahareh Ajami, Jami Bennett, Charles Krieger et al. · Nature Neuroscience · 2007 · 1.6K citations

, , +14

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

Julia Marschallinger, Tal Iram, Macy E. Zardeneta et al. · Nature Neuroscience · 2020 · 1.4K citations · Full text

, , +16

Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

Suzanne E. Hickman, Elizabeth Allison, Joseph El Khoury · Journal of Neuroscience · 2008 · 1.3K citations · Full text

, , +17

Microglial brain region−dependent diversity and selective regional sensitivities to aging

Kathleen Grabert, Tom Michoel, Michail H. Karavolos et al. · Nature Neuroscience · 2016 · 1.2K citations · Full text

, , +14

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

Dunja Mrdjen, Anto Pavlovic, Felix J. Hartmann et al. · Immunity · 2018 · 1K citations · Full text

, , +12

1–5 of 303

Authors

2.1K

  1. JP
    Jonathan P. Godbout

    The Ohio State University, United States

    10 publications · 2.4K citations

    10

    h-index

  2. WJ
    Wolfgang J. Streit

    University of Florida, United States

    7 publications · 2.3K citations

    7

    h-index

  3. RW
    Rodney W. Johnson

    University of Illinois Urbana-Champaign, United States

    6 publications · 1.4K citations

    6

    h-index

  4. BJ
    Bart J. L. Eggen

    University of Groningen, Netherlands

    6 publications · 1.1K citations

    6

    h-index

  5. LD
    Louise D. McCullough

    The University of Texas Health Science Center at Houston, United States

    5 publications · 354 citations

    5

    h-index

1–5 of 2.1K

Institutions

631

  1. Institute for Behavioral Medicine

    Smyrna, United States

    12 h-index

    25 publications

    3.1K citations

  2. Harvard University

    Cambridge, United States

    12 h-index

    36 publications

    4.8K citations

  3. The Ohio State University

    Columbus, United States

    12 h-index

    38 publications

    6.8K citations

  4. University of Illinois Urbana-Champaign

    Urbana, United States

    11 h-index

    45 publications

    9.4K citations

  5. German Center for Neurodegenerative Diseases

    Bonn, Germany

    9 h-index

    51 publications

    10.5K citations

  6. The University of Texas Health Science Center at Houston

    Houston, United States

    9 h-index

    55 publications

    2.2K citations

  7. University of Groningen

    Groningen, The Netherlands

    8 h-index

    48 publications

    10.1K citations

  8. University of Florida

    Gainesville, United States

    8 h-index

    15 publications

    5.6K citations

1–8 of 631

Venues

  1. Neurobiology of Aging

    25 publications · 2.8K citations

    21

    h-index

  2. Glia

    18 publications · 3.4K citations

    17

    h-index

  3. Journal of Neuroinflammation

    JNI · 11 publications · 1.2K citations

    11

    h-index

  4. Aging Cell

    10 publications · 1.6K citations

    10

    h-index

  5. Brain Behavior and Immunity

    10 publications · 1.8K citations

    10

    h-index

1–5