Concepedia

Age-dependent Clearance

Age-Dependent Clearance is a pharmacokinetic construct that characterizes the maturation-related changes in drug elimination capacity across pediatric populations by quantifying clearance as a function of age-specific physiological development.

102

Publications

5.5K

Citations

430

Authors

217

Institutions

Publications per year

2017–2026

13

Parents

Publications

102

Evaluation of Child/Adult Pharmacokinetic Differences from a Database Derived from the Therapeutic Drug Literature

Gary Ginsberg · Toxicological Sciences · 2002 · 331 citations

, , +17

Factors affecting theophylline clearances: Age, tobacco, marijuana, cirrhosis, congestive heart failure, obesity, oral contraceptives, benzodiazepines, barbiturates, and ethanol

William J. Jusko, Mark Gardner, Antoinette Mangione et al. · Journal of Pharmaceutical Sciences · 1979 · 252 citations

, , +15

Morphine Pharmacokinetics in Early Infancy

Anne M Lynn, John T. Slattery · Anesthesiology · 1987 · 243 citations · Full text

, , +16

IgG-Assisted Age-Dependent Clearance of Alzheimer's Amyloid β Peptide by the Blood–Brain Barrier Neonatal Fc Receptor

Rashid Deane, Abhay P. Sagare, Katie Hamm et al. · Journal of Neuroscience · 2005 · 232 citations · Full text

, , +17

A Mechanistic Approach for the Scaling of Clearance in Children

Andrea N. Edginton, Walter Schmitt, Barbara Voith et al. · Clinical Pharmacokinetics · 2006 · 217 citations

, , +6

1–5 of 102

Authors

430

  1. BJ
    Brian J. Anderson

    University of Auckland, New Zealand

    7 publications · 480 citations

    7

    h-index

  2. KA
    Karel Allegaert

    KU Leuven, Belgium

    6 publications · 420 citations

    6

    h-index

  3. EH
    Elke H. J. Krekels

    Leiden University, Netherlands

    4 publications · 188 citations

    4

    h-index

  4. MD
    Meindert Danhof

    Leiden University, Netherlands

    4 publications · 240 citations

    4

    h-index

  5. IM
    Iftekhar Mahmood

    Center for Biologics Evaluation and Research, United States

    4 publications · 145 citations

    4

    h-index

1–5 of 430

Institutions

217

  1. University of Auckland

    Auckland, New Zealand

    7 h-index

    17 publications

    1.4K citations

  2. Leiden University

    Leiden, The Netherlands

    7 h-index

    20 publications

    960 citations

  3. Centre for Human Drug Research

    Leiden, The Netherlands

    6 h-index

    15 publications

    511 citations

  4. Cincinnati Children's Hospital Medical Center

    Cincinnati, United States

    5 h-index

    17 publications

    933 citations

  5. KU Leuven

    Leuven, Belgium

    5 h-index

    8 publications

    360 citations

  6. St. Antonius Ziekenhuis

    Nieuwegein, The Netherlands

    4 h-index

    5 publications

    268 citations

  7. Center for Drug Evaluation and Research

    Silver Spring, United States

    4 h-index

    10 publications

    256 citations

  8. University of Cincinnati Medical Center

    Cincinnati, United States

    4 h-index

    14 publications

    691 citations

1–8 of 217

Venues

  1. British Journal of Clinical Pharmacology

    BJCP · 9 publications · 600 citations

    9

    h-index

  2. The Journal of Clinical Pharmacology

    8 publications · 262 citations

    8

    h-index

  3. Clinical Pharmacokinetics

    7 publications · 524 citations

    7

    h-index

  4. CPT Pharmacometrics & Systems Pharmacology

    PSP · 6 publications · 149 citations

    6

    h-index

  5. Therapeutic Drug Monitoring

    5 publications · 304 citations

    5

    h-index

1–5