Concepedia

Affinity-based Targeting

Affinity-Based Targeting is a drug targeting strategy that relies on the selective binding interaction between a therapeutic agent and a specific molecular target, distinguished by the exploitation of high-affinity ligand-receptor or antigen-antibody interactions to achieve precise delivery to diseased cells or tissues.

34

Publications

2.4K

Citations

274

Authors

94

Institutions

Publications per year

2017–2026

10

Parents

Publications

34

Influence of Affinity and Antigen Internalization on the Uptake and Penetration of Anti-HER2 Antibodies in Solid Tumors

Stephen I. Rudnick, Jianlong Lou, Calvin Shaller et al. · Cancer Research · 2011 · 351 citations · Full text

, , +17

Identification of a small molecule with activity against drug-resistant and persistent tuberculosis

Feng Wang, Dhinakaran Sambandan, Rajkumar Halder et al. · Proceedings of the National Academy of Sciences · 2013 · 226 citations · Full text

, , +17

Developing Photoactive Affinity Probes for Proteomic Profiling:  Hydroxamate-based Probes for Metalloproteases

Elaine W.S. Chan, Souvik Chattopadhaya, Resmi C. Panicker et al. · Journal of the American Chemical Society · 2004 · 222 citations

, , +17

A High-Affinity Human Antibody That Targets Tumoral Blood Vessels

Lorenzo Tarli, Enrica Balza, Francesca Viti et al. · Blood · 1999 · 209 citations

, , +14

Impact of Single-chain Fv Antibody Fragment Affinity on Nanoparticle Targeting of Epidermal Growth Factor Receptor-expressing Tumor Cells

Yu Zhou, Daryl C. Drummond, Hao Zou et al. · Journal of Molecular Biology · 2007 · 150 citations

, , +14

1–5 of 34

Authors

274

  1. SQ
    Shao Q. Yao

    National University of Singapore, Singapore

    4 publications · 338 citations

    4

    h-index

  2. JW
    Jesper Wengel

    University of Southern Denmark, Denmark

    4 publications · 176 citations

    4

    h-index

  3. AP
    Adriaan P. IJzerman

    Centre for Human Drug Research, Netherlands

    2 publications · 63 citations

    2

    h-index

  4. EW
    Elaine W.S. Chan

    National University of Singapore, Singapore

    2 publications · 249 citations

    2

    h-index

  5. YY
    Yinhua Yang

    MacroGenics (United States), United States

    2 publications · 226 citations

    2

    h-index

1–5 of 274

Institutions

94

  1. National University of Singapore

    Singapore, Singapore

    4 h-index

    15 publications

    1.5K citations

  2. University of Southern Denmark

    Odense, Denmark

    4 h-index

    11 publications

    457 citations

  3. Albert Einstein College of Medicine

    Bronx, United States

    2 h-index

    6 publications

    1.2K citations

  4. Université Bourgogne Franche-Comté

    Besançon, France

    2 h-index

    5 publications

    276 citations

  5. University of Washington

    Seattle, United States

    2 h-index

    10 publications

    324 citations

  6. MacroGenics (United States)

    Rockville, United States

    2 h-index

    16 publications

    1.8K citations

  7. Leiden University

    Leiden, The Netherlands

    2 h-index

    16 publications

    504 citations

  8. University of California, San Francisco

    San Francisco, United States

    2 h-index

    11 publications

    3.3K citations

1–8 of 94

Venues

  1. Chemical Communications

    ChemComm · 3 publications · 123 citations

    3

    h-index

  2. PubMed

    Repository · 2 publications · 63 citations

    2

    h-index

  3. Journal of Endocrinology

    1 publications · 22 citations

    1

    h-index

  4. Angewandte Chemie International Edition

    1 publications · 34 citations

    1

    h-index

  5. Journal of Molecular Biology

    JMB · 1 publications · 150 citations

    1

    h-index

1–5