Concepedia

Adaptive Combinations Design

Adaptive Combinations Design is a class of adaptive experimental design that integrates multiple treatment arms and outcome measures within a single trial framework, allowing pre-specified modifications to treatment combinations or patient allocation based on accumulating data to optimize therapeutic efficacy and trial efficiency.

8

Publications

434

Citations

37

Authors

11

Institutions

Publications per year

2017–2026

1

Parents

Publications

8

Adaptive Dunnett tests for treatment selection

Franz Koenig, Werner Brannath, Frank Bretz et al. · Statistics in Medicine · 2007 · 129 citations

, , +15

Issues in designing flexible trials

Martin Posch, Péter Bauer, Werner Brannath · Statistics in Medicine · 2003 · 109 citations

, , +16

Adaptive designs for selecting drug combinations based on efficacy–toxicity response

Vladimir Dragalin, Valerii V. Fedorov, Yuehui Wu · Journal of Statistical Planning and Inference · 2007 · 72 citations

, , +9

Type I error rate control in adaptive designs for confirmatory clinical trials with treatment selection at interim

Martin Posch, Willi Maurer, Frank Bretz · Pharmaceutical Statistics · 2010 · 49 citations

, , +16

Flexible Analytical Methods for Adding a Treatment Arm Mid-Study to an Ongoing Clinical Trial

Jordan J. Elm, Yuko Y. Palesch, Gary G. Koch et al. · Journal of Biopharmaceutical Statistics · 2012 · 23 citations · Full text

, , +16

1–5 of 8

Authors

37

  1. MP
    Martin Posch

    Medical University of Vienna, Austria

    3 publications · 287 citations

    3

    h-index

  2. WB
    Werner Brannath

    Medical University of Vienna, Austria

    2 publications · 238 citations

    2

    h-index

  3. FB
    Frank Bretz

    Novartis (Switzerland), Switzerland

    2 publications · 178 citations

    2

    h-index

  4. VV
    Valerii V. Fedorov

    GlaxoSmithKline (United States), United States

    1 publications · 72 citations

    1

    h-index

  5. WZ
    Wenle Zhao

    Medical University of South Carolina, United States

    1 publications · 23 citations

    1

    h-index

1–5 of 37

Institutions

11

  1. Medical University of Vienna

    Vienna, Austria

    2 h-index

    4 publications

    436 citations

  2. Novartis (Switzerland)

    Basel, Switzerland

    2 h-index

    3 publications

    227 citations

  3. GlaxoSmithKline (United States)

    Philadelphia, United States

    1 h-index

    3 publications

    216 citations

  4. University of Virginia

    Charlottesville, United States

    1 h-index

    3 publications

    63 citations

  5. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    1 h-index

    1 publications

    23 citations

  6. Humboldt-Universität zu Berlin

    Berlin, Germany

    1 h-index

    18 publications

    216 citations

  7. University of Rochester

    Rochester, United States

    1 h-index

    1 publications

    23 citations

  8. Charité - Universitätsmedizin Berlin

    Berlin, Germany

    1 h-index

    1 publications

    12 citations

1–8 of 11

Venues

  1. Statistics in Medicine

    2 publications · 238 citations

    2

    h-index

  2. Annals of Oncology

    1 publications · 21 citations

    1

    h-index

  3. Journal of Statistical Planning and Inference

    1 publications · 72 citations

    1

    h-index

  4. Journal of Biopharmaceutical Statistics

    JBS · 1 publications · 23 citations

    1

    h-index

  5. Pharmaceutical Statistics

    1 publications · 49 citations

    1

    h-index

1–5