Concepedia

Acyl-enzyme Intermediates

Acyl-Enzyme Intermediates is a transient covalent complex formed during enzymatic catalysis in which an acyl group is covalently bound to a nucleophilic residue in the enzyme’s active site, distinguishing it from non-covalent intermediates by enabling subsequent hydrolysis or transfer reactions through covalent bond stabilization.

225

Publications

12.3K

Citations

786

Authors

244

Institutions

Publications per year

2017–2026

19

Variants

Acyl-enzyme Intermediate

Parents

Publications

225

Molecular structure of the acyl-enzyme intermediate in β-lactam hydrolysis at 1.7 Å resolution

N.C.J. Strynadka, Hiroyuki Adachi, Susan E. Jensen et al. · Nature · 1992 · 526 citations

, , +15

Organocatalytic Enantioselective Acyl Transfer onto Racemic as well as <i>meso</i> Alcohols, Amines, and Thiols

Christa E. Müller, Peter R. Schreiner · Angewandte Chemie International Edition · 2011 · 376 citations

, , +16

An Antigenic Peptide Produced by Peptide Splicing in the Proteasome

Nathalie Vigneron, Vincent Stroobant, Jacques Chapiro et al. · Science · 2004 · 329 citations

, , +17

Serpin-Protease Complexes Are Trapped as Stable Acyl-Enzyme Intermediates

Daniel A. Lawrence, David Ginsburg, Duane E. Day et al. · Journal of Biological Chemistry · 1995 · 247 citations · Full text

, , +17

Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site

Jaeyong Lee, L.J. Worrall, M. Vuckovic et al. · Nature Communications · 2020 · 232 citations · Full text

, , +17

1–5 of 225

Authors

786

  1. ML
    Myron L. Bender

    Northwestern University, United States

    8 publications · 456 citations

    8

    h-index

  2. CT
    Christopher T. Walsh

    Harvard University, United States

    8 publications · 595 citations

    8

    h-index

  3. RF
    R. F. Pratt

    Wesleyan University, United States

    7 publications · 211 citations

    7

    h-index

  4. PC
    Paul Carey

    Case Western Reserve University, United States

    6 publications · 198 citations

    6

    h-index

  5. CJ
    Christopher J. Schofield

    University of Oxford, United Kingdom

    6 publications · 224 citations

    6

    h-index

1–5 of 786

Institutions

244

  1. Harvard University

    Cambridge, United States

    13 h-index

    44 publications

    3.6K citations

  2. University of Oxford

    Oxford, United Kingdom

    9 h-index

    33 publications

    1.3K citations

  3. University of Illinois Urbana-Champaign

    Urbana, United States

    8 h-index

    32 publications

    2.5K citations

  4. Case Western Reserve University

    Cleveland, United States

    8 h-index

    37 publications

    1.4K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    7 h-index

    22 publications

    2.1K citations

  6. National Institutes of Health

    Bethesda, United States

    6 h-index

    13 publications

    788 citations

  7. University of Notre Dame

    Notre Dame, United States

    5 h-index

    22 publications

    1K citations

  8. Wesleyan University

    Middletown, United States

    5 h-index

    14 publications

    294 citations

1–8 of 244

Venues

  1. Biochemistry

    48 publications · 2.8K citations

    35

    h-index

  2. Journal of Biological Chemistry

    JBC · 44 publications · 2.5K citations

    27

    h-index

  3. Journal of the American Chemical Society

    JACS · 23 publications · 1.2K citations

    19

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 12 publications · 832 citations

    12

    h-index

  5. Biochemical Journal

    BJ · 12 publications · 340 citations

    11

    h-index

1–5