Concepedia

Activity-directed Synthesis

Activity-Directed Synthesis is a hit discovery method that integrates biological activity data into the synthetic design process, prioritizing the construction of compounds with optimized target engagement through iterative feedback between synthesis and phenotypic or biochemical screening.

27

Publications

968

Citations

113

Authors

40

Institutions

Publications per year

2017–2026

14

Parents

Publications

27

The Preparation of Catena Compounds by Directed Synthesis

Gottfried Schill, Arthur Lüttringhaus · Angewandte Chemie International Edition in English · 1964 · 177 citations

, , +10

11-Step Total Synthesis of (−)-Maoecrystal V

Artiom Cernijenko, Rune Risgaard, Phil S. Baran · Journal of the American Chemical Society · 2016 · 120 citations · Full text

, , +16

Re-engineering natural products to engage new biological targets

Stephen E. Motika, Paul J. Hergenrother · Natural Product Reports · 2020 · 66 citations · Full text

, , +14

Efficient discovery of bioactive scaffolds by activity-directed synthesis

George Karageorgis, Stuart L. Warriner, Adam Nelson · Nature Chemistry · 2014 · 65 citations

, , +16

Engineered Synthesis of 7-Oxo- and 15-Deoxy-15-Oxo-Amphotericins: Insights into Structure-Activity Relationships in Polyene Antibiotics

Patrick Power, Terence Dunne, Barry Murphy et al. · Chemistry & Biology · 2008 · 49 citations

, , +14

1–5 of 27

Authors

113

  1. AN
    Adam Nelson

    University of Leeds, United Kingdom

    4 publications · 130 citations

    5

    h-index

  2. SL
    Stuart L. Warriner

    University of Leeds, United Kingdom

    4 publications · 130 citations

    4

    h-index

  3. GK
    George Karageorgis

    University of Leeds, United Kingdom

    2 publications · 97 citations

    3

    h-index

  4. AI
    Adam I. Green

    University of Leeds, United Kingdom

    1 publications · 16 citations

    1

    h-index

  5. PP
    Patrick Power

    University College Dublin, Ireland

    1 publications · 49 citations

    1

    h-index

1–5 of 113

Institutions

40

  1. University of Leeds

    Leeds, United Kingdom

    5 h-index

    19 publications

    537 citations

  2. Scripps Research Institute

    San Diego, United States

    2 h-index

    6 publications

    471 citations

  3. University of Freiburg

    Freiburg im Breisgau, Germany

    2 h-index

    4 publications

    388 citations

  4. Institute of Structural and Molecular Biology

    London, United Kingdom

    2 h-index

    9 publications

    198 citations

  5. Chinese Academy of Sciences

    Beijing, China

    1 h-index

    3 publications

    63 citations

  6. Consejo Nacional de Investigaciones Científicas y Técnicas

    Buenos Aires, Argentina

    1 h-index

    4 publications

    64 citations

  7. University of Illinois System

    Urbana, United States

    1 h-index

    2 publications

    132 citations

  8. Johnson & Johnson (United States)

    New Brunswick, United States

    1 h-index

    2 publications

    42 citations

1–8 of 40

Venues

  1. Journal of Medicinal Chemistry

    2 publications · 61 citations

    2

    h-index

  2. Chemical Communications

    ChemComm · 2 publications · 54 citations

    2

    h-index

  3. Nature Chemistry

    2 publications · 94 citations

    2

    h-index

  4. Angewandte Chemie International Edition

    1 publications · 32 citations

    1

    h-index

  5. Medicinal Chemistry Research

    1 publications · 15 citations

    1

    h-index

1–5