Concepedia

Active Site Loop Dynamics

Active Site Loop Dynamics is a theoretical construct in enzymology that characterizes the conformational fluctuations of loop regions surrounding the active site of an enzyme, distinguished by its focus on the dynamic rearrangements that modulate substrate access, binding, and catalytic turnover.

119

Publications

6.2K

Citations

490

Authors

198

Institutions

Publications per year

2017–2026

22

Parents

Publications

119

Loop and Subdomain Movements in the Mechanism of <i>Escherichia coli </i>Dihydrofolate Reductase:  Crystallographic Evidence<sup>,</sup>

M.R. Sawaya, Joseph Kraut · Biochemistry · 1997 · 666 citations

, , +17

Protein Dynamics in Enzymatic Catalysis:  Exploration of Dihydrofolate Reductase

Jennifer L. Radkiewicz, Charles L. Brooks · Journal of the American Chemical Society · 1999 · 316 citations

, , +17

Backbone Dynamics in Dihydrofolate Reductase Complexes:  Role of Loop Flexibility in the Catalytic Mechanism

Michael J. Osborne, Jason R. Schnell, Stephen J. Benkovic et al. · Biochemistry · 2001 · 253 citations

, , +17

Conformational Motions Regulate Phosphoryl Transfer in Related Protein Tyrosine Phosphatases

Sean K. Whittier, Alvan C. Hengge, J. Patrick Loria · Science · 2013 · 235 citations · Full text

, , +17

The Structure of the Staphylococcus aureus Sortase-Substrate Complex Reveals How the Universally Conserved LPXTG Sorting Signal Is Recognized

Nuttee Suree, Chu Kong Liew, Valerie A. Villareal et al. · Journal of Biological Chemistry · 2009 · 218 citations · Full text

, , +17

1–5 of 119

Authors

490

  1. PE
    Peter E. Wright

    Scripps Research Institute, United States

    6 publications · 719 citations

    6

    h-index

  2. HJ
    H. Jane Dyson

    Scripps Research Institute, United States

    5 publications · 595 citations

    5

    h-index

  3. AE
    Ann E. McDermott

    Columbia University, United States

    4 publications · 522 citations

    4

    h-index

  4. FJ
    Frank Jordan

    Rutgers, The State University of New Jersey, United States

    4 publications · 155 citations

    4

    h-index

  5. JR
    Jason R. Schnell

    University of Oxford, United Kingdom

    4 publications · 580 citations

    4

    h-index

1–5 of 490

Institutions

198

  1. Scripps Research Institute

    San Diego, United States

    7 h-index

    28 publications

    3.9K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    7 h-index

    24 publications

    825 citations

  3. Albert Einstein College of Medicine

    Bronx, United States

    7 h-index

    33 publications

    1.4K citations

  4. Columbia University

    New York, United States

    6 h-index

    17 publications

    1.6K citations

  5. Yale University

    New Haven, United States

    6 h-index

    11 publications

    740 citations

  6. University of California San Diego

    San Diego, United States

    6 h-index

    16 publications

    1.8K citations

  7. Pennsylvania State University

    State College, United States

    6 h-index

    18 publications

    1.7K citations

  8. Howard Hughes Medical Institute

    Chevy Chase, United States

    5 h-index

    10 publications

    417 citations

1–8 of 198

Venues

  1. Biochemistry

    34 publications · 2.3K citations

    23

    h-index

  2. Journal of Molecular Biology

    JMB · 11 publications · 673 citations

    11

    h-index

  3. Journal of Biological Chemistry

    JBC · 5 publications · 385 citations

    5

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 5 publications · 414 citations

    5

    h-index

  5. Biophysical Journal

    5 publications · 289 citations

    5

    h-index

1–5