Concepedia

Active Comparator Design

Active Comparator Design is a type of clinical study design in which the intervention under investigation is compared against an already established, actively used treatment rather than a placebo or no treatment, thereby enabling the assessment of relative effectiveness or safety within real-world evidence research.

202

Publications

15.8K

Citations

1.9K

Authors

847

Institutions

Publications per year

2017–2026

118

Parents

Publications

202

Trials to assess equivalence: the importance of rigorous methods: Fig 1

Byron Jones, Philip Jarvis, John A. Lewis et al. · BMJ · 1996 · 1K citations

, , +13

Efficacy and safety of guselkumab, an anti-interleukin-23 monoclonal antibody, compared with adalimumab for the continuous treatment of patients with moderate to severe psoriasis: Results from the phase III, double-blinded, placebo- and active comparator–controlled VOYAGE 1 trial

Andrew Blauvelt, Kim Papp, C.E.M. Griffiths et al. · Journal of the American Academy of Dermatology · 2017 · 860 citations · Full text

, , +17

Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial

Juan P. Frías, Michael A. Nauck, Joanna Van et al. · The Lancet · 2018 · 799 citations

, , +17

Efficacy and safety of guselkumab, an anti-interleukin-23 monoclonal antibody, compared with adalimumab for the treatment of patients with moderate to severe psoriasis with randomized withdrawal and retreatment: Results from the phase III, double-blind, placebo- and active comparator–controlled VOYAGE 2 trial

Kristian Reich, April W. Armstrong, Peter Foley et al. · Journal of the American Academy of Dermatology · 2017 · 731 citations · Full text

, , +15

The Active Comparator, New User Study Design in Pharmacoepidemiology: Historical Foundations and Contemporary Application

Jennifer L. Lund, David B. Richardson, Til Stürmer‎ · Current Epidemiology Reports · 2015 · 691 citations · Full text

, , +9

1–5 of 202

Authors

1.9K

  1. BP
    Björn Pasternak

    Statens Serum Institut, Denmark

    5 publications · 305 citations

    5

    h-index

  2. VW
    Viktor Wintzell

    Karolinska Institutet, Sweden

    5 publications · 305 citations

    5

    h-index

  3. KR
    Kristian Reich

    Dermatologikum Hamburg, Germany

    5 publications · 1.7K citations

    5

    h-index

  4. OH
    Oriana Hoi Yun Yu

    McGill University, Canada

    5 publications · 276 citations

    5

    h-index

  5. HS
    Henrik Svanström

    Statens Serum Institut, Denmark

    5 publications · 305 citations

    5

    h-index

1–5 of 1.9K

Institutions

847

  1. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    12 h-index

    55 publications

    4.1K citations

  2. Harvard University

    Cambridge, United States

    9 h-index

    25 publications

    1.8K citations

  3. Karolinska Institutet

    Stockholm, Sweden

    9 h-index

    42 publications

    3K citations

  4. Jewish General Hospital

    Montreal, Canada

    8 h-index

    32 publications

    1.6K citations

  5. Eli Lilly (United States)

    Indianapolis, United States

    7 h-index

    32 publications

    5.7K citations

  6. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    7 h-index

    19 publications

    2.5K citations

  7. McGill University

    Montreal, Canada

    7 h-index

    22 publications

    1K citations

  8. Brigham and Women's Hospital

    Boston, United States

    7 h-index

    18 publications

    738 citations

1–8 of 847

Venues

  1. Diabetes Care

    6 publications · 531 citations

    6

    h-index

  2. Diabetes Obesity and Metabolism

    5 publications · 265 citations

    5

    h-index

  3. Current Medical Research and Opinion

    CMRO · 5 publications · 191 citations

    5

    h-index

  4. JAMA Network Open

    5 publications · 171 citations

    5

    h-index

  5. Clinical Therapeutics

    5 publications · 505 citations

    5

    h-index

1–5