Concepedia

48S Initiation Complex

The "48S Initiation Complex" is a eukaryotic translation preinitiation complex comprising the small ribosomal subunit 40S, initiator methionyl-tRNA, and initiation factors that assembles at the 5′ cap of an mRNA and scans toward the start codon to initiate protein synthesis.

53

Publications

4.4K

Citations

167

Authors

84

Institutions

Publications per year

2017–2026

14

Parents

Publications

53

Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology.

Arrigo De Benedetti, Robert E. Rhoads · Proceedings of the National Academy of Sciences · 1990 · 283 citations

, , +17

Structure of a human 48 <i>S</i> translational initiation complex

Jailson Brito Querido, Masaaki Sokabe, S.H.W. Kraatz et al. · Science · 2020 · 283 citations · Full text

, , +17

5 Mechanism and Regulation of Initiator Methionyl-tRNA Binding to Ribosomes

Alan G. Hinnebusch · Cold Spring Harbor Monograph Archive · 2000 · 247 citations

, , +17

Structural Changes Enable Start Codon Recognition by the Eukaryotic Translation Initiation Complex

Tanweer Hussain, J.L. Llacer, I.S. Fernandez et al. · Cell · 2014 · 232 citations · Full text

, , +17

Release of initiation factors from 48S complexes during ribosomal subunit joining and the link between establishment of codon-anticodon base-pairing and hydrolysis of eIF2-bound GTP

Anett Unbehaun, Sergei Borukhov, Christopher U.T. Hellen et al. · Genes & Development · 2004 · 221 citations · Full text

, , +17

1–5 of 53

Authors

167

  1. AV
    Andrey V. Pisarev

    SUNY Downstate Health Sciences University, United States

    6 publications · 432 citations

    6

    h-index

  2. AG
    Alan G. Hinnebusch

    Eunice Kennedy Shriver National Institute of Child Health and Human Development, United States

    6 publications · 739 citations

    6

    h-index

  3. CU
    Christopher U.T. Hellen

    SUNY Downstate Health Sciences University, United States

    5 publications · 572 citations

    5

    h-index

  4. YG
    Yuliya Gordiyenko

    MRC Laboratory of Molecular Biology, United Kingdom

    5 publications · 545 citations

    5

    h-index

  5. TV
    Tatyana V. Pestova

    SUNY Downstate Health Sciences University, United States

    5 publications · 572 citations

    5

    h-index

1–5 of 167

Institutions

84

  1. Lomonosov Moscow State University

    Moscow, Russia

    8 h-index

    25 publications

    2.2K citations

  2. SUNY Downstate Health Sciences University

    Brooklyn, United States

    7 h-index

    23 publications

    2.7K citations

  3. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    7 h-index

    25 publications

    3.4K citations

  4. University of California, Davis

    Davis, United States

    6 h-index

    13 publications

    1.8K citations

  5. Eunice Kennedy Shriver National Institute of Child Health and Human Development

    Bethesda, United States

    6 h-index

    17 publications

    1.8K citations

  6. National Institutes of Health

    Bethesda, United States

    5 h-index

    15 publications

    1.7K citations

  7. Case Western Reserve University

    Cleveland, United States

    4 h-index

    9 publications

    1.6K citations

  8. State University of New York

    Albany, United States

    4 h-index

    16 publications

    2.5K citations

1–8 of 84

Venues

  1. Journal of Biological Chemistry

    JBC · 12 publications · 1K citations

    12

    h-index

  2. Nucleic Acids Research

    9 publications · 387 citations

    9

    h-index

  3. RNA

    6 publications · 269 citations

    6

    h-index

  4. Molecular and Cellular Biology

    MCB · 3 publications · 282 citations

    3

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 338 citations

    3

    h-index

1–5