Concepedia

43S Pre-initiation Complex

The 43S Pre-Initiation Complex is a eukaryotic translation initiation intermediate that comprises the small ribosomal subunit 40S, associated initiation factors (including eIF1, eIF1A, eIF3, and eIF5), and the initiator methionyl-tRNA base-paired to the start codon in the P-site, distinguishing it from other pre-initiation assemblies by its readiness to scan the mRNA and commit to translation initiation.

63

Publications

6K

Citations

239

Authors

91

Institutions

Publications per year

2017–2026

11

Variants

43S Pic

Parents

Publications

63

Evidence That Ternary Complex (eIF2-GTP-tRNA<sub>i</sub><sup>Met</sup>)–Deficient Preinitiation Complexes Are Core Constituents of Mammalian Stress Granules

Nancy Kedersha, Samantha Chen, Natalie Gilks et al. · Molecular Biology of the Cell · 2002 · 626 citations · Full text

, , +17

Mechanism of ribosome recruitment by hepatitis C IRES RNA

Jeffrey S. Kieft, Kaihong Zhou, Ronald Jubin et al. · RNA · 2001 · 363 citations · Full text

, , +17

Functional Dissection of Eukaryotic Initiation Factor 4F: the 4A Subunit and the Central Domain of the 4G Subunit Are Sufficient To Mediate Internal Entry of 43S Preinitiation Complexes

Tatyana V. Pestova, Ivan N. Shatsky, Christopher U.T. Hellen · Molecular and Cellular Biology · 1996 · 345 citations · Full text

, , +17

Iron regulatory protein prevents binding of the 43S translation pre‐initiation complex to ferritin and eALAS mRNAs.

Nicola K. Gray, Matthias W. Hentze · The EMBO Journal · 1994 · 279 citations · Full text

, , +14

Structure of mammalian eIF3 in the context of the 43S preinitiation complex

Amédée des Georges, Vidya Dhote, Lauriane Kühn et al. · Nature · 2015 · 278 citations

, , +10

1–5 of 63

Authors

239

  1. TV
    Tatyana V. Pestova

    SUNY Downstate Health Sciences University, United States

    11 publications · 1.8K citations

    11

    h-index

  2. CU
    Christopher U.T. Hellen

    SUNY Downstate Health Sciences University, United States

    11 publications · 1.8K citations

    11

    h-index

  3. AG
    Alan G. Hinnebusch

    Eunice Kennedy Shriver National Institute of Child Health and Human Development, United States

    8 publications · 801 citations

    8

    h-index

  4. LS
    Leoš Shivaya Valášek

    Czech Academy of Sciences, Institute of Microbiology, Czechia

    7 publications · 378 citations

    7

    h-index

  5. ID
    Irene Díaz‐López

    Universidad Autónoma de Madrid, Spain

    6 publications · 180 citations

    6

    h-index

1–5 of 239

Institutions

91

  1. Czech Academy of Sciences, Institute of Microbiology

    Prague, Czechia

    8 h-index

    28 publications

    1.6K citations

  2. SUNY Downstate Health Sciences University

    Brooklyn, United States

    7 h-index

    27 publications

    4.4K citations

  3. Eunice Kennedy Shriver National Institute of Child Health and Human Development

    Bethesda, United States

    7 h-index

    20 publications

    1.8K citations

  4. State University of New York

    Albany, United States

    6 h-index

    20 publications

    3.9K citations

  5. Lomonosov Moscow State University

    Moscow, Russia

    5 h-index

    9 publications

    1.9K citations

  6. National Institutes of Health

    Bethesda, United States

    5 h-index

    16 publications

    1.3K citations

  7. Johns Hopkins Medicine

    Baltimore, United States

    4 h-index

    15 publications

    1.7K citations

  8. Czech Academy of Sciences

    Prague, Czechia

    4 h-index

    11 publications

    449 citations

1–8 of 91

Venues

  1. Journal of Biological Chemistry

    JBC · 14 publications · 741 citations

    13

    h-index

  2. Nucleic Acids Research

    11 publications · 411 citations

    11

    h-index

  3. RNA

    6 publications · 819 citations

    6

    h-index

  4. Molecular and Cellular Biology

    MCB · 4 publications · 670 citations

    4

    h-index

  5. Cold Spring Harbor Monograph Archive

    2 publications · 310 citations

    2

    h-index

1–5