Concepedia

2'-O-methyl Modification

2'-O-Methyl Modification is a chemical modification of RNA in which a methyl group is added to the 2'-hydroxyl group of the ribose sugar, enhancing nuclease resistance and binding affinity while reducing immunogenicity compared to unmodified RNA.

513

Publications

53.6K

Citations

2.2K

Authors

659

Institutions

Publications per year

2017–2026

117

Variants

2'-O-methylation2'-Ome Modification

Parents

Publications

513

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

Guifang Jia, Ye Fu, Xu Zhao et al. · Nature Chemical Biology · 2011 · 4.1K citations

, , +11

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

Guanqun Zheng, John Arne Dahl, Yamei Niu et al. · Molecular Cell · 2012 · 3.7K citations · Full text

, , +7

Identification of Methylated Nucleosides in Messenger RNA from Novikoff Hepatoma Cells

Ronald C. Desrosiers, Karen H. Friderici, Fritz Rottman · Proceedings of the National Academy of Sciences · 1974 · 1.8K citations · Full text

, , +14

FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N 6 -Methyladenosine RNA Demethylase

Zejuan Li, Hengyou Weng, Rui Su et al. · Cancer Cell · 2016 · 1.6K citations

, , +17

The Obesity-Associated <i>FTO</i> Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase

Thomas Gerken, Christophe A. Girard, Yi‐Chun Loraine Tung et al. · Science · 2007 · 1.5K citations · Full text

, , +9

1–5 of 513

Authors

2.2K

  1. FR
    Fritz Rottman

    Case Western Reserve University, United States

    11 publications · 3K citations

    11

    h-index

  2. CH
    Chuan He

    University of Chicago, United States

    11 publications · 11.9K citations

    11

    h-index

  3. QD
    Qing Dai

    University of Chicago, United States

    9 publications · 10K citations

    9

    h-index

  4. MG
    Marvin Gold

    University of Toronto, Canada

    8 publications · 745 citations

    8

    h-index

  5. JH
    Jerard Hurwitz

    Memorial Sloan Kettering Cancer Center, United States

    7 publications · 683 citations

    7

    h-index

1–5 of 2.2K

Institutions

659

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    20 h-index

    62 publications

    23.9K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    18 h-index

    79 publications

    5K citations

  3. University of Chicago

    Chicago, United States

    18 h-index

    119 publications

    111.1K citations

  4. Chinese Academy of Sciences

    Beijing, China

    13 h-index

    73 publications

    65.6K citations

  5. Inserm

    Paris, France

    10 h-index

    34 publications

    1.6K citations

  6. Albert Einstein College of Medicine

    Bronx, United States

    9 h-index

    23 publications

    2.4K citations

  7. National Institutes of Health

    Bethesda, United States

    8 h-index

    17 publications

    805 citations

  8. Tokyo Institute of Technology

    Tokyo, Japan

    8 h-index

    30 publications

    521 citations

1–8 of 659

Venues

  1. Nucleic Acids Research

    51 publications · 5.6K citations

    35

    h-index

  2. Biochemistry

    44 publications · 1.9K citations

    29

    h-index

  3. Journal of Biological Chemistry

    JBC · 23 publications · 2.3K citations

    20

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 16 publications · 3.5K citations

    15

    h-index

  5. RNA

    16 publications · 2.3K citations

    15

    h-index

1–5