21:I[432972,["/_next/static/chunks/bb923814e1f4d2e9.js","/_next/static/chunks/dd3ee9f5b7716ca6.js","/_next/static/chunks/4204a0ae82542ca8.js","/_next/static/chunks/1270dead247da766.js","/_next/static/chunks/6e1aa89a642f40be.js","/_next/static/chunks/2d7aa753e81324a8.js","/_next/static/chunks/8ffd0b71567920d8.js","/_next/static/chunks/67ea6dfd21f16c5f.js","/_next/static/chunks/24eb4379f68013fd.js","/_next/static/chunks/b8cd775ffdf935bd.js","/_next/static/chunks/983103cd9eb7b428.js","/_next/static/chunks/263f2cdcb9aa2341.js","/_next/static/chunks/294b9525248c8e5f.js"],"default"] 22:T4b3,The aim is to explore the underlying mechanism of basic leucine zipper ATF-like transcription factor 2 (BATF2) in tongue squamous cell carcinoma (TSCC). The expression of BATF2 in TSCC tissues and corresponding adjacent normal TSCC tissues, human TSCC cell lines (SCC-15 and CAL-27) and human normal tongue epithelial cells NTEC was detected. Then, SCC-15 cells with stable BATF2 knockdown and CAL-27 cells with BATF2 overexpression were established to investigate the functional effect of BATF2 on TSCC. Thereafter, the effect of BATF2 on TSCC angiogenesis and BATF2 m6A methylation was also examined. BATF2 was significantly downregulated in TSCC tissues and cell lines, and BATF2 overexpression could suppress growth, metastasis and angiogenesis of TSCC. Mechanistically, vascular endothelial growth factor A (VEGFA) was identified as a downstream gene of BATF2, and it was confirmed that BATF2 suppressed growth, metastasis and angiogenesis of TSCC via inhibiting VEGFA. In addition, the N6-methyladenosine (m6A) modification of BATF2 mRNA mediated by METTL14 suppressed its expression in TSCC. METTL14/BATF2 axis could serve as a novel promising therapeutic candidate against angiogenesis for TSCC.23:T506,Gold nanoclusters (AuNCs) are highly promising for applications in photothermal conversion due to their exceptional surface area and optical properties. However, their high surface energy often leads to aggregation, compromising stability and performance. To address this, we developed a ferritin-inspired covalent organic cage with a near-enclosed cavity to physically stabilize AuNCs. This superphane cage coordinates with Au³⁺ ions, forming highly stable and uniform AuNCs upon reduction. The encapsulated AuNCs exhibit broad absorption (250-2500 nm) and achieve remarkable photothermal conversion efficiency of 92.8% under 808 nm laser irradiation. At low power densities (0.5 W/cm²), temperatures reach 150 °C, and under one-sun illumination (1 kW/m²), the solar-to-vapor generation efficiency reaches 95.1%, with a water evaporation rate of 2.35 kg m^-2 h^-1. Even after 20 seawater desalination cycles, the system maintains a stable evaporation rate of 2.24 kg m^-2 h^-1, demonstrating excellent salt tolerance and durability. This ferritin-inspired strategy offers a robust platform for enhancing the stability and performance of AuNCs, advancing sustainable energy and water purification technologies.

#	Concept	H-Index	Publications	Citations
1	Medicine	6	6	179
2	Cell Biology	3	3	80
3	Engineering	2	2	58
4	Biochemistry	1	1	54
5	Diabetes	1	1	19

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