Sintilimab plus bevacizumab biosimilar IBI305 and chemotherapy for patients with EGFR-mutated non-squamous non-small-cell lung cancer who progressed on EGFR tyrosine-kinase inhibitor therapy (ORIENT-31): first interim results from a randomised, double-blind, multicentre, phase 3 trial

Shun Lü, Lin Wu, Hong Jian, +24

The Lancet Oncology

OncologyFirst Interim ResultsBevacizumab Biosimilar Ibi305Clinical TrialsPathology +8

Genistein Induces Pancreatic β-Cell Proliferation through Activation of Multiple Signaling Pathways and Prevents Insulin-Deficient Diabetes in Mice

Zhuo Fu, Wen Zhang, Zhen Wei, +7

Endocrinology

Sintilimab plus chemotherapy for patients with EGFR-mutated non-squamous non-small-cell lung cancer with disease progression after EGFR tyrosine-kinase inhibitor therapy (ORIENT-31): second interim analysis from a double-blind, randomised, placebo-controlled, phase 3 trial

Shun Lü, Lin Wu, Hong Jian, +23

The Lancet Respiratory Medicine

OncologyDisease ProgressionSecond Interim AnalysisMetronomic TherapyClinical Trials +7

NF-kappaB-dependent MicroRNA-425 upregulation promotes gastric cancer cell growth by targeting PTEN upon IL-1β induction

Jun Ma, Jun Liu, Zhiming Wang, +6

Molecular Cancer

Tensin HomologImmunologyImmune RegulationCancer BiologyTumor Biology +14

Epidemiologic and genomic insights on mcr-1-harbouring Salmonella from diarrhoeal outpatients in Shanghai, China, 2006–2016

Xin Lü, Mei Zeng, Jialiang Xu, +11

EBioMedicine

A dual-mode sensor for colorimetric and fluorescent detection of nitrite in hams based on carbon dots-neutral red system

Xuetao Hu, Jiyong Shi, Yongqiang Shi, +7

Meat Science

Chemical EngineeringEngineeringSensorsNatural SciencesSpectroscopy +8

Geochemical Stability of Dissolved Mn(III) in the Presence of Pyrophosphate as a Model Ligand: Complexation and Disproportionation

Ao Qian, Wen Zhang, Cheng Shi, +5

Environmental Science & Technology

Deubiquitinase USP35 restrains STING-mediated interferon signaling in ovarian cancer

Jiawen Zhang, Yunfei Chen, Xianfei Chen, +9

Cell Death and Differentiation

MedicineDeubiquitinase Usp35Cancer BiologyCell BiologyCell Signaling +3

Establishing a New Benchmark in Quantum Computational Advantage with 105-qubit Zuchongzhi 3.0 Processor

Dongxin Gao, Daojin Fan, Chen Zha, +138

Physical Review Letters

EngineeringComputer ArchitectureNew BenchmarkZuchongzhi 3.0105-Qubit Zuchongzhi 3.0 +20

Minocycline alleviates NLRP3 inflammasome-dependent pyroptosis in monosodium glutamate-induced depressive rats

Feng Yang, Wen Zhu, Xiaofang Cai, +7

Biochemical and Biophysical Research Communications

InflammationMolecular PharmacologyAnti-inflammatoryMedicinePhysiology +11