Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma

Naoya Mimura, Mariateresa Fulciniti, Güllü Görgün, +22

Blood

Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy

Susan E. Logue, Eoghan P. McGrath, Patricia A. Cleary, +16

Nature Communications

Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer

Na Zhao, Jin Cao, Longyong Xu, +33

Journal of Clinical Investigation

Tumor BiologyOncogenic MycSystems BiologyOncologyBreast Oncology +12

IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling

Xia Sheng, Hatice Zeynep Nenseth, Su Qu, +13

Nature Communications

Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors

Mário Sanches, Nicole M. Duffy, Manisha Talukdar, +20

Nature Communications

Molecular PharmacologyAldehyde DehydrogenaseBiochemistryMedicineNatural Sciences +7

Design and synthesis of fluoroquinophenoxazines that interact with human telomeric G-quadruplexes and their biological effects.

Wenhu Duan, Anupama Rangan, Hariprasad Vankayalapati, +10

PubMed

Bioorganic ChemistryMolecular BiologyOrganic ChemistryHeterocycle ChemistryChemical Biology +14

Local intracerebral inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo

Pierre‐Jean Le Reste, Raphaël Pineau, Konstantinos Voutetakis, +15

Cancer Letters

Neuro-oncologyRadiation TherapyGliomaMedicineLocal Intracerebral Inhibition +9

Synthesis of pyrrolizidine alkaloids via rhodium-catalyzed silylformylation and amidocarbonylation

Masakatsu Eguchi, Qingping Zeng, Anna Korda, +1

Tetrahedron Letters

Organic ChemistryPyrrolizidine AlkaloidsChemistryNatural Product SynthesisSynthetic Chemistry

Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β

Aaron Talty, Shane Deegan, Mila Ljujić, +9

Cell Death and Disease

Disruption of microRNA Biogenesis Confers Resistance to ER Stress-Induced Cell Death Upstream of the Mitochondrion

Karen Cawley, Susan E. Logue, Adrienne M. Gorman, +4

PLoS ONE

GeneticsApoptosisCell DeathTumor BiologyOxidative Stress +15