Yuyuan Jin

Discovery of an Exceptionally Orally Bioavailable and Potent HPK1 PROTAC with Enhancement of Antitumor Efficacy of Anti-PD-L1 Therapy

Mingfei Wu, Yiquan Wu, Yuyuan Jin et al. · Journal of Medicinal Chemistry · 2024 · 20 citations · Full text

Discovery of highly efficient CRBN-recruiting HPK1-PROTAC as a potential chemical tool for investigation of scaffolding roles in TCR signaling

Shenxin Zeng, Yuyuan Jin, Heye Xia et al. · Bioorganic Chemistry · 2023 · 18 citations

Signal Transduction, Signaling Pathway, Molecular Regulation +11

Discovery of a potent and selective PARP1 degrader promoting cell cycle arrest via intercepting CDC25C-CDK1 axis for treating triple-negative breast cancer

Yiquan Wu, Mingfei Wu, Xiaoli Zheng et al. · Bioorganic Chemistry · 2023 · 17 citations

Breast Oncology, Medicine, Selective Parp1 Degrader +7

Discovery of novel, potent, selective and orally bioavailable HPK1 inhibitor for enhancing the efficacy of anti-PD-L1 antibody

Shenxin Zeng, Mingfei Wu, Yuyuan Jin et al. · European Journal of Medicinal Chemistry · 2024 · 16 citations · Full text

Anti-pd-l1 Antibody, Medicine, Immunology +8

Discovery of potent and selective HPK1 inhibitors based on the 2,4-disubstituted pyrimidine scaffold with immune modulatory properties for ameliorating T cell exhaustion

Shenxin Zeng, Ming Zeng, Shuai Yuan et al. · Bioorganic Chemistry · 2023 · 14 citations

Medicine, T-regulatory Cell, Selective Hpk1 Inhibitors +12