DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1

Yusuke Ogitani, Tetsuo Aida, Katsunobu Hagihara, +13

Clinical Cancer Research

A NOVEL MODEL OF CONTINUOUS DEPLETION OF GLUTATHIONE IN MICE TREATED WITH L-BUTHIONINE(S,R)-SULFOXIMINE.

Toshiyuki Watanabe, Hideki Sagisaka, Shingo Arakawa, +7

The Journal of Toxicological Sciences

Lipid PeroxidationExperimental PharmacologyOxidative StressRemarkable NecrosisDrinking Water +14

Sensitivity of Liver Injury in Heterozygous <i>Sod2</i> Knockout Mice Treated with Troglitazone or Acetaminophen

Kazunori Fujimoto, Kazuyoshi Kumagai, Kazumi Ito, +4

Toxicologic Pathology

Troglitazone-induced Liver InjuryLipid PeroxidationCell DeathPharmacotherapyOxidative Stress +14

Effects of Restricted Feeding on Daily Fluctuations of Hepatic Functions Including P450 Monooxygenase Activities in Rats

Jun Hirao, Shingo Arakawa, Kyoko Watanabe, +2

Journal of Biological Chemistry

Sex and circadian modulatory effects on rat liver as assessed by transcriptome analyses

Jun Hirao, Masatoshi Nishimura, Shingo Arakawa, +7

The Journal of Toxicological Sciences

GeneticsCircadian Modulatory EffectsTranscriptional RegulationTranscription Factors Sp1Transcriptome Analyses +17

Phosphorylation of Farnesoid X Receptor at Serine 154 Links Ligand Activation With Degradation

Takuyu Hashiguchi, Shingo Arakawa, Shogo Takahashi, +3

Molecular Endocrinology

Molecular BiologyFarnesoid X ReceptorNonproteasome PathwaysSignaling PathwayReceptor Tyrosine Kinase +16

Resistance to acetaminophen-induced hepatotoxicity in &lt;i&gt;glutathione S-transferase Mu 1&lt;/i&gt;-null mice

Shingo Arakawa, Takanori Maejima, Kazunori Fujimoto, +5

The Journal of Toxicological Sciences

ApoptosisPhosphorylated Jnk-Null MiceToxicological MechanismJnk Phosphorylation +14

Characterization of Phenotypes in Gstm1-null Mice by Cytosolic and in Vivo Metabolic Studies Using 1,2-Dichloro-4-Nitrobenzene

Kazunori Fujimoto, Shingo Arakawa, Yukari Shibaya, +8

Drug Metabolism and Disposition

Role of connexin 32 in acetaminophen toxicity in a knockout mice model

Isao Igarashi, Takanori Maejima, Kiyonori Kai, +3

Experimental and Toxicologic Pathology

ImmunologyExperimental PharmacologyGsh TransmissionToxicological MechanismOxidative Stress +16

Generation and Functional Characterization of Mice with a Disrupted Glutathione S-Transferase, Theta 1 Gene

Kazunori Fujimoto, Shingo Arakawa, Toshiyuki Watanabe, +5

Drug Metabolism and Disposition