Samantha Lien

Engineering Human IgG1 Affinity to Human Neonatal Fc Receptor: Impact of Affinity Improvement on Pharmacokinetics in Primates

Yik A. Yeung, Maya K. Leabman, Jonathan S. Marvin et al. · The Journal of Immunology · 2009 · 235 citations · Full text

Pharmacy, Immunology, Pharmacokinetics +14

Ranibizumab inhibits multiple forms of biologically active vascular endothelial growth factor in vitro and in vivo

John R. Lowe, James Araujo, Jihong Yang et al. · Experimental Eye Research · 2007 · 166 citations

Medicine, Pharmacology, Pharmacotherapy +14

Establishing a Link Between Amino Acid Sequences and Self-Associating and Viscoelastic Behavior of Two Closely Related Monoclonal Antibodies

Sandeep Yadav, Alavattam Sreedhara, Sonoko Kanai et al. · Pharmaceutical Research · 2011 · 126 citations

Life Sciences, Biochemistry, Molecular Biology +16

Pharmacokinetics of Humanized Monoclonal Anti-Tumor Necrosis Factor-α Antibody and Its Neonatal Fc Receptor Variants in Mice and Cynomolgus Monkeys

Rong Deng, Kelly M. Loyet, Samantha Lien et al. · Drug Metabolism and Disposition · 2010 · 110 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

A Therapeutic Anti–VEGF Antibody with Increased Potency Independent of Pharmacokinetic Half-life

Yik A. Yeung, Xiumin Wu, Arthur E. Reyes et al. · Cancer Research · 2010 · 79 citations

Pharmacy, Oncology, Pharmacology +17