RhoBTB1 protects against hypertension and arterial stiffness by restraining phosphodiesterase 5 activity

Masashi Mukohda, Shi Fang, Jing Wu, +11

Journal of Clinical Investigation

HypertensionGenetic ComplementationCardiovascular FunctionVascular Smooth MuscleMolecular Pharmacology +15

Retinol-binding protein 7 is an endothelium-specific PPARγ cofactor mediating an antioxidant response through adiponectin

Chunyan Hu, Henry L. Keen, Ko‐Ting Lu, +7

JCI Insight

Pparγ ActivityRetinol-binding Protein 7Oxidative StressInflammationMetabolic Syndrome +19

Interference with PPARγ in endothelium accelerates angiotensin II-induced endothelial dysfunction

Chunyan Hu, Ko‐Ting Lu, Masashi Mukohda, +3

Physiological Genomics

HypertensionAng Ii InfusionIi-induced Endothelial DysfunctionBlood PressureOxidative Stress +16

Hypertension-Causing Mutation in Peroxisome Proliferator–Activated Receptor γ Impairs Nuclear Export of Nuclear Factor-κB p65 in Vascular Smooth Muscle

Masashi Mukohda, Ko‐Ting Lu, Deng‐Fu Guo, +8

Hypertension

Protective Role for Tissue Inhibitor of Metalloproteinase-4, a Novel Peroxisome Proliferator–Activated Receptor-γ Target Gene, in Smooth Muscle in Deoxycorticosterone Acetate–Salt Hypertension

Pimonrat Ketsawatsomkron, Henry L. Keen, Deborah R. Davis, +7

Hypertension

Pparγ ActivityHypertensionRenal InflammationNovel PeroxisomeCardiovascular Function +24

Estrogen Receptor α Is Required for Maintaining Baseline Renin Expression

Ko‐Ting Lu, Henry L. Keen, Eric T. Weatherford, +3

Hypertension

Molecular RegulationGeneticsRenal InflammationRenin ExpressionTranscriptional Regulation +23

EP3 (E-Prostanoid 3) Receptor Mediates Impaired Vasodilation in a Mouse Model of Salt-Sensitive Hypertension

Jing Wu, Shi Fang, Ko‐Ting Lu, +5

Hypertension

Nervous System Expression of PPARγ and Mutant PPARγ Has Profound Effects on Metabolic Regulation and Brain Development

Madeliene Stump, Deng‐Fu Guo, Ko‐Ting Lu, +5

Endocrinology

Effect of selective expression of dominant-negative PPARγ in pro-opiomelanocortin neurons on the control of energy balance

Madeliene Stump, Deng‐Fu Guo, Ko‐Ting Lu, +4

Physiological Genomics

RhoBTB1 reverses established arterial stiffness in angiotensin II–induced hypertension by promoting actin depolymerization

Shi Fang, Jing Wu, John J. Reho, +12

JCI Insight

HypertensionEngineeringCardiovascular PharmacologyRhobtb1 RestorationActin Depolymerization +15