MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors

Brian J.P. Huntly, Hirokazu Shigematsu, Kenji Deguchi, +9

Cancer Cell

Hematological MalignancyDevelopmental BiologyConfers PropertiesMedicineHematology +9

Mouse Development and Cell Proliferation in the Absence of D-Cyclins

Katarzyna Kozar, Maria A. Ciemerych, Vivienne I. Rebel, +9

Cell

Knockout MouseDevelopmental BiologyCell DivisionCell ProliferationCell Cycle +5

Enhancement of Hematopoietic Stem Cell Repopulating Capacity and Self-Renewal in the Absence of the Transcription Factor C/EBPα

Pu Zhang, Junko Iwasaki-Arai, Hiromi Iwasaki, +9

Immunity

Transcription Factor C/ebpαDevelopmental BiologyMedicineStem Cell MobilizationHematology +6

Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype

Joseph D. Growney, Hirokazu Shigematsu, Zhe Li, +9

Blood

Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation

Hiromi Iwasaki, Chamorro Somoza, Hirokazu Shigematsu, +15

Blood

Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis

Yojiro Arinobu, Hiromi Iwasaki, Michael F. Gurish, +6

Proceedings of the National Academy of Sciences

Reciprocal Activation of GATA-1 and PU.1 Marks Initial Specification of Hematopoietic Stem Cells into Myeloerythroid and Myelolymphoid Lineages

Yojiro Arinobu, Shin-ichi Mizuno, Yong Chong, +8

Cell stem cell

Developmental BiologyReciprocal ActivationMedicineGeneticsStem Cell Mobilization +11

The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages

Hiromi Iwasaki, Shin-ichi Mizuno, Yojiro Arinobu, +6

Genes & Development

Lymphocyte DevelopmentGeneticsLineage SpecificationMolecular GeneticsMultipotent Stem Cells +18

Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations

M. Golam Mohi, Ifor R. Williams, Charles R. Dearolf, +10

Cancer Cell

Knockout MouseGenome InstabilitySignal TransductionMixed-phenotype Acute LeukemiaSystems Biology +5

Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease

Iris T. Chan, Jeffery L. Kutok, Ifor R. Williams, +8

Journal of Clinical Investigation