Inhibition of activin receptor-like kinase 5 attenuates Bleomycin-induced pulmonary fibrosis

Hiroyuki Higashiyama, Daisuke Yoshimoto, Toshihiko Kaise, +5

Experimental and Molecular Pathology

InflammationFibrosisAntifibrotic TherapyInflammatory Lung DiseaseBleomycin-induced Pulmonary Fibrosis +10

Neurochemical responses to antidepressants in the prefrontal cortex of mice and their efficacy in preclinical models of anxiety-like and depression-like behavior: a comparative and correlational study

Tomohiro Kobayashi, Etsuko Hayashi, Midori Shimamura, +2

Psychopharmacology

Prefrontal CortexPsychotropic MedicationAffective NeurosciencePsychopharmacologyPsychology +14

Immunolocalization of farnesoid X receptor (FXR) in mouse tissues using tissue microarray

Hiroyuki Higashiyama, Mine Kinoshita, S Asano

Acta Histochemica

XenotransplantationMedicineImmunologyFarnesoid X ReceptorTissue Microarray +4

Expression profiling of Peroxisome proliferator-activated receptor-delta (PPAR-delta) in mouse tissues using tissue microarray

Hiroyuki Higashiyama, Andrew N. Billin, Yuji Okamoto, +2

Histochemistry and Cell Biology

Signal TransductionMolecular PhysiologyBiomarker TargetTissue MicroarrayExpression Profiling +8

Changes in micro-CT 3D bone parameters reflect effects of a potent cathepsin K inhibitor (SB-553484) on bone resorption and cortical bone formation in ovariectomized mice

Anbo Xiang, Masahiro Kanematsu, Sanjay Kumar, +5

Bone

Tissue EngineeringEngineeringBone ResorptionMedicineMicro-ct 3D +10

Kv7.2–7.5 voltage-gated potassium channel (KCNQ2–5) opener, retigabine, reduces capsaicin-induced visceral pain in mice

Kazufumi Hirano, Kazuyoshi Kuratani, Masato Fujiyoshi, +3

Neuroscience Letters

Health SciencesHyperpolarization (Biology)Pain MedicineCapsaicin-induced Visceral PainPhysiology +9

Ecabet sodium, a locally acting antiulcer drug, inhibits urease activity of Helicobacter pylori

Kazuo Shibata, Aiko Hongo, Mine Kinoshita

European Journal of Pharmacology

BiochemistryMedicineActing Antiulcer DrugPharmacologyDrug Discovery +2

Receptor-activated Smad localisation in Bleomycin-induced pulmonary fibrosis

Hiroyuki Higashiyama, Daisuke Yoshimoto, Yuji Okamoto, +3

Journal of Clinical Pathology

Comparison of mitochondrial and macrophage content between subcutaneous and visceral fat in db/db mice

Yuji Okamoto, Hiroyuki Higashiyama, James X. Rong, +4

Experimental and Molecular Pathology

ObesityMetabolic SyndromeInflammationLipid AnalysisBody Composition +10

In vitro and in vivo transdermal iontophoretic delivery of naloxone, an opioid antagonist

Rie Yamamoto, Shinri Takasuga, Yoshimasa Yoshida, +8

International Journal of Pharmaceutics

MedicineOpioid AntagonistPharmacotherapyOpioid OverdoseAnesthesia +5