BRD4 PROTAC degrader ARV-825 inhibits T-cell acute lymphoblastic leukemia by targeting 'Undruggable' Myc-pathway genes

Shuiyan Wu, You Jiang, Yi Hong, +17

Cancer Cell International

Survivin selective inhibitor YM155 induce apoptosis in SK-NEP-1 Wilms tumor cells

Yanfang Tao, Jun Lu, Xiaojuan Du, +12

BMC Cancer

Metallothionein III (MT3) is a putative tumor suppressor gene that is frequently inactivated in pediatric acute myeloid leukemia by promoter hypermethylation

Yanfang Tao, Lixiao Xu, Jun Lu, +18

Journal of Translational Medicine

Molecular mechanism of G1 arrest and cellular senescence induced by LEE011, a novel CDK4/CDK6 inhibitor, in leukemia cells

Yanfang Tao, Nana Wang, Lixiao Xu, +17

Cancer Cell International

PROTAC Bromodomain Inhibitor ARV-825 Displays Anti-Tumor Activity in Neuroblastoma by Repressing Expression of MYCN or c-Myc

Zhi-Heng Li, Su Lin Lim, Yanfang Tao, +21

Frontiers in Oncology

Inhibiting PLK1 induces autophagy of acute myeloid leukemia cells via mammalian target of rapamycin pathway dephosphorylation

Yanfang Tao, Zhiheng Li, Weiwei Du, +17

Oncology Reports

Cell AutophagyMitophagyMammalian TargetSignal TransductionRapamycin Pathway Dephosphorylation +13

Early B-cell factor 3 (EBF3) is a novel tumor suppressor gene with promoter hypermethylation in pediatric acute myeloid leukemia

Yanfang Tao, Lixiao Xu, Jun Lu, +24

Journal of Experimental & Clinical Cancer Research

ARV-825 Demonstrates Antitumor Activity in Gastric Cancer via MYC-Targets and G2M-Checkpoint Signaling Pathways

Xinmei Liao, Xiaoqing Qian, Zimu Zhang, +15

Frontiers in Oncology

BRD4 inhibitor MZ1 exerts anti-cancer effects by targeting MYCN and MAPK signaling in neuroblastoma

Xianbing Zhang, Xinyi Guo, Ran Zhuo, +16

Biochemical and Biophysical Research Communications

Brd4 Inhibitor Mz1Anti-cancer EffectsMedicineCell BiologyTumor Suppressor +5

Histone acetyltransferase inhibitor II induces apoptosis in glioma cell lines via the p53 signaling pathway

Lixiao Xu, Zhi-Heng Li, Yanfang Tao, +7

Journal of Experimental & Clinical Cancer Research