Jenifer A. Brown

Extracellular cGAMP is a cancer-cell-produced immunotransmitter involved in radiation-induced anticancer immunity

Jacqueline A. Carozza, Volker Böhnert, Khanh Cong Nguyen et al. · Nature Cancer · 2020 · 317 citations · Full text

Radiation-induced Anticancer Immunity, Cancer Immunosurveillance, Malignant Disease +11

Structure-Aided Development of Small-Molecule Inhibitors of ENPP1, the Extracellular Phosphodiesterase of the Immunotransmitter cGAMP

Jacqueline A. Carozza, Jenifer A. Brown, Volker Böhnert et al. · Cell chemical biology · 2020 · 103 citations · Full text

Signal Transduction, G Protein-coupled Receptor, Structure-aided Development +9

ENPP1’s regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling

Jacqueline A. Carozza, Anthony F. Cordova, Jenifer A. Brown et al. · Proceedings of the National Academy of Sciences · 2022 · 87 citations · Full text

2’3’-cGAMP is an immunotransmitter produced by cancer cells and regulated by ENPP1

Jacqueline A. Carozza, Volker Böhnert, Kelsey E. Shaw et al. · 2019 · 19 citations · Full text

Immunology, Immune Regulation, Immunoediting +21