Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation

Seth L. Masters, Vasiliki Lagou, Isabelle Jéru, +29

Science Translational Medicine

Disease-associated mutations identify a novel region in human STING necessary for the control of type I interferon signaling

Isabelle Melki, Y Rose, Carolina Uggenti, +23

Journal of Allergy and Clinical Immunology

Signal TransductionNovel RegionDisease-associated MutationsGeneticsPathogenesis +7

Innovative Randomized Phase I Study and Dosing Regimen Selection to Accelerate and Inform Pivotal COVID‐19 Trial of Nirmatrelvir

Ravi Shankar Prasad Singh, Sima S. Toussi, Frances Hackman, +13

Clinical Pharmacology & Therapeutics

Brief Report: <i>IFIH1</i> Mutation Causes Systemic Lupus Erythematosus With Selective IgA Deficiency

Lien Van Eyck, Lien De Somer, Diana Pombal, +8

Arthritis & Rheumatology

Genetic and phenotypic spectrum associated with IFIH1 gain‐of‐function

Gillian Rice, Sehoon Park, Francesco Gavazzi, +60

Human Mutation

Olmsted syndrome: exploration of the immunological phenotype

Dina Danso‐Abeam, Jianguo Zhang, James Dooley, +16

Orphanet Journal of Rare Diseases

Machine learning identifies an immunological pattern associated with multiple juvenile idiopathic arthritis subtypes

Erika Van Nieuwenhove, Vasiliki Lagou, Lien Van Eyck, +8

Annals of the Rheumatic Diseases

ADA2 Deficiency Mimicking Idiopathic Multicentric Castleman Disease

Erika Van Nieuwenhove, Stéphanie Humblet‐Baron, Lien Van Eyck, +6

PEDIATRICS

Metabolism and Excretion of Nirmatrelvir in Humans Using Quantitative Fluorine Nuclear Magnetic Resonance Spectroscopy: A Novel Approach for Accelerating Drug Development

Ravi Shankar Prasad Singh, Gregory S. Walker, Eugene P. Kadar, +9

Clinical Pharmacology & Therapeutics

Brief Report: Blockade of TANK‐Binding Kinase 1/IKKɛ Inhibits Mutant Stimulator of Interferon Genes (STING)–Mediated Inflammatory Responses in Human Peripheral Blood Mononuclear Cells

Marie‐Louise Frémond, Carolina Uggenti, Lien Van Eyck, +10

Arthritis & Rheumatology