Asymmetric Hydrogenation of Unsaturated Ureas with the BIPI Ligands

Carl A. Busacca, Jon C. Lorenz, Nelu Grinberg, +8

Organic Letters

Inorganic ChemistryEngineeringChiral Rhodium CatalystsHydrogen BondOrganic Chemistry +10

Structure–Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97

Celeste Alverez, Michelle R. Arkin, Stacie L. Bulfer, +11

ACS Medicinal Chemistry Letters

Combinatorial ChemistryBioorganic ChemistryIndole CoreLead IdentificationOrganic Chemistry +16

Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway

Celeste Alverez, Stacie L. Bulfer, Ramappa Chakrasali, +15

ACS Medicinal Chemistry Letters

Indole AmideMedicinal ChemistryDrug TargetDrug Discovery EffortsBiochemistry +13

Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors

Matthew G. LaPorte, Zhuzhu Wang, Raffaele Colombo, +13

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesRational Drug Design +8

Complete reversal of Lambert–Eaton myasthenic syndrome synaptic impairment by the combined use of a K⁺ channel blocker and a Ca²⁺ channel agonist

Tyler B. Tarr, David Lacomis, Stephen Reddel, +5

The Journal of Physiology

Synthesis and Biological Evaluation of a Selective N- and P/Q-Type Calcium Channel Agonist

Mary Liang, Tyler B. Tarr, Karla Bravo‐Altamirano, +9

ACS Medicinal Chemistry Letters

Effectiveness of Analogs of the GS-Nitroxide, JP4-039, as Total Body Irradiation Mitigators

Michael W. Epperly, Joshua R. Sacher, Tanja Krainz, +7

In Vivo

Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding

Annette Chiang, Mary Liang, Antonio Dominguez‐Meijide, +11

Bioorganic & Medicinal Chemistry

Protein ChemistryProtein FunctionProtein AssemblyBiochemistryProtein Folding +9

New Cav2 calcium channel gating modifiers with agonist activity and therapeutic potential to treat neuromuscular disease

Man Wu, Hayley V. White, Blake A. Boehm, +9

Neuropharmacology

Therapeutic PotentialKinesiologyHyperpolarization (Biology)NeurophysiologyAgonist Activity +8

New calcium channel agonists as potential therapeutics in Lambert–Eaton myasthenic syndrome and other neuromuscular diseases

Tyler B. Tarr, Guillermo Valdomir, Mary Liang, +2

Annals of the New York Academy of Sciences

Muscle FunctionCalcium ChannelsNeuromuscular BlockadeNeuromuscular JunctionPotential Therapeutics +16