Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation

Jasper Iske, Midas Seyda, Timm Heinbokel, +12

Nature Communications

Targeting age‐specific changes in CD4⁺ T cell metabolism ameliorates alloimmune responses and prolongs graft survival

Yeqi Nian, Jasper Iske, Ryoichi Maenosono, +10

Aging Cell

Recipient sex and estradiol levels affect transplant outcomes in an age-specific fashion

Ryoichi Maenosono, Yeqi Nian, Jasper Iske, +11

American Journal of Transplantation

Mast cells regulate CD4+ T-cell differentiation in the absence of antigen presentation

Héctor Rodríguez Cetina Biefer, Timm Heinbokel, Hirofumi Uehara, +13

Journal of Allergy and Clinical Immunology

Transplanting old organs promotes senescence in young recipients

Jasper Iske, Maximilian J. Roesel, Friederike Martin, +17

American Journal of Transplantation

Regenerative MedicineLifespan ExtensionDevelopmental BiologyAnti-agingAging +4

Taurodeoxycholic acid and valine reverse obesity-associated augmented alloimmune responses and prolong allograft survival

Markus Quante, Jasper Iske, Hirofumi Uehara, +11

American Journal of Transplantation

ObesityMetabolic SyndromeTaurodeoxycholic AcidXenotransplantationTransplantation +8

Comparison of Fast-Track Versus Conventional Surgery Protocol for Patients Undergoing Robot-Assisted Laparoscopic Radical Prostatectomy: A Chinese Experience

Zhichao Huang, Yi Lu, Zhaohui Zhong, +6

Scientific Reports

CAV3.1 knockdown suppresses cell proliferation, migration and invasion of prostate cancer cells by inhibiting AKT

Shanbiao Hu, Ling Li, Wei Huang, +8

Cancer Management and Research

CTLA4-Ig prolongs graft survival specifically in young but not old mice

Timm Heinbokel, Markus Quante, Jasper Iske, +7

American Journal of Transplantation

Knockout MouseCell TherapyTransplantationXenotransplantationOld Mice +8

Restored TDCA and valine levels imitate the effects of bariatric surgery

Markus Quante, Jasper Iske, Timm Heinbokel, +20

eLife