Defective Endoplasmic Reticulum-resident Membrane Protein CLN6 Affects Lysosomal Degradation of Endocytosed Arylsulfatase A

Claudia Heine, Bettina Koch, Stephan Storch, +3

Journal of Biological Chemistry

Association between an Emerging Disseminated form of Leishmaniasis and Leishmania (Viannia) braziliensis Strain Polymorphisms

Adriano Queiroz, Rosana S. Sousa, Claudia Heine, +7

Journal of Clinical Microbiology

Parasitic DiseaseBraziliensis PopulationGeneticsMucosal LeishmaniasisGenetic Epidemiology +16

Rodent Cortical Astroglia Express In Situ Functional P2X7 Receptors Sensing Pathologically High ATP Concentrations

João Filipe Oliveira, Thomas Riedel, Anna Leichsenring, +5

Cerebral Cortex

Discovery of olodaterol, a novel inhaled β2-adrenoceptor agonist with a 24 h bronchodilatory efficacy

Thierry Bouyssou, Christoph Hoenke, K Rudolf, +8

Bioorganic & Medicinal Chemistry Letters

Novel interactions of CLN5 support molecular networking between Neuronal Ceroid Lipofuscinosis proteins

Annina Lyly, Carina von Schantz, Claudia Heine, +4

BMC Cell Biology

Changes of the GPR17 receptor, a new target for neurorepair, in neurons and glial cells in patients with traumatic brain injury

Heike Franke, Chiara Parravicini, Davide Lecca, +10

Purinergic Signalling

Traumatic Brain InjuryNeuroregenerationGpr17 ReceptorMedicinePharmacology +12

Optimized polyethylenimine (PEI)-based nanoparticles for siRNA delivery, analyzed in vitro and in an ex vivo tumor tissue slice culture model

Alexander Ewe, Sabrina Höbel, Claudia Heine, +6

Drug Delivery and Translational Research

Tissue EngineeringNanomedicineNanoparticlesEngineeringPolymer-drug Conjugate +6

The neuronal ceroid lipofuscinosis protein CLN5: new insights into cellular maturation, transport, and consequences of mutations

Mia-Lisa Schmiedt, Carlos Bessa, Claudia Heine, +3

Human Mutation

Molecular BiologyCytoskeletonNew InsightsCellular PhysiologyEpendyma +16

Topology and endoplasmic reticulum retention signals of the lysosomal storage disease-related membrane protein CLN6

Claudia Heine, Claudia Heine, Arne Quitsch, +6

Molecular Membrane Biology

Er LocalizationMolecular BiologyCellular PhysiologyProtein FoldingAutophagy +16

Enhanced expression of manganese-dependent superoxide dismutase in human and sheep CLN6 tissues

Claudia Heine, Jaana Tyynelä, Jonathan D. Cooper, +4

Biochemical Journal

Mitochondrial DysfunctionLipid PeroxidationPathologyCell DeathManganese-dependent Superoxide Dismutase +16