High Basal Protein Kinase A–Dependent Phosphorylation Drives Rhythmic Internal Ca ²⁺ Store Oscillations and Spontaneous Beating of Cardiac Pacemaker Cells

Tatiana M. Vinogradova, Alexey E. Lyashkov, Weizhong Zhu, +13

Circulation Research

Familial Hypertrophic Cardiomyopathy-Linked Mutant Troponin T Causes Stress-Induced Ventricular Tachycardia and Ca ²⁺ -Dependent Action Potential Remodeling

Björn C. Knollmann, Paulus Kirchhof, Syevda Sirenko, +7

Circulation Research

Cardiac MuscleHeart FailureGeneticsCardiovascular GeneticsCellular Ca2+ Transients +14

Constitutive Phosphodiesterase Activity Restricts Spontaneous Beating Rate of Cardiac Pacemaker Cells by Suppressing Local Ca ²⁺ Releases

Tatiana M. Vinogradova, Syevda Sirenko, Alexey E. Lyashkov, +7

Circulation Research

Cardiac MuscleNeurotransmitterCardiac Pacemaker CellsPharmacotherapyCardiovascular Function +16

Sarcoplasmic Reticulum Ca ²⁺ Pumping Kinetics Regulates Timing of Local Ca ²⁺ Releases and Spontaneous Beating Rate of Rabbit Sinoatrial Node Pacemaker Cells

Tatiana M. Vinogradova, Didier X.P. Brochet, Syevda Sirenko, +3

Circulation Research

Synchronization of Stochastic Ca2+ Release Units Creates a Rhythmic Ca2+ Clock in Cardiac Pacemaker Cells

Anna Maltsev, Victor A. Maltsev, Maxim Mikheev, +4

Biophysical Journal

Cardiac MuscleRhythmic Ca2+ ClockPhysiologyCardiac Pacemaker CellsElectrophysiology +6

New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: Bradycardic effects of ivabradine are linked to suppression of intracellular Ca2+ cycling

Yael Yaniv, Syevda Sirenko, Bruce D. Ziman, +3

Journal of Molecular and Cellular Cardiology

Cardiac MuscleElectrophysiological EvaluationMedicinePhysiologyNew Evidence +6

F110I and R278C Troponin T Mutations That Cause Familial Hypertrophic Cardiomyopathy Affect Muscle Contraction in Transgenic Mice and Reconstituted Human Cardiac Fibers

Olga M. Hernandez, Danuta Szczesna‐Cordary, Björn C. Knollmann, +10

Journal of Biological Chemistry

Action potential characterization in intact mouse heart: steady-state cycle length dependence and electrical restitution

Björn C. Knollmann, Tilmann Schober, Andreas O. Petersen, +2

American Journal of Physiology-Heart and Circulatory Physiology

Early ApdCardiac MuscleHeart FailureIntact Mouse HeartBiomedical Engineering +21

Targeted point mutagenesis of mouse Kcnq1: phenotypic analysis of mice with point mutations that cause Romano-Ward syndrome in humans

Mathew C. Casimiro, Björn C. Knollmann, Ebenezer N. Yamoah, +8

Genomics

Knockout MouseGenome InstabilityPoint MutationsGenetic DisorderGenetics +7

Mammalian γ2 AMPK regulates intrinsic heart rate

Arash Yavari, Mohamed Bellahcene, Annalisa Bucchi, +61

Nature Communications