Applications of Differential Scanning Calorimetry for Thermal Stability Analysis of Proteins: Qualification of DSC

Jie Wen, Kelly K. Arthur, Letha Chemmalil, +3

Journal of Pharmaceutical Sciences

EngineeringDerivative ThermogravimetryBiochemistryDifferential Scanning CalorimetryProtein Folding +9

Detection of Protein Aggregates by Sedimentation Velocity Analytical Ultracentrifugation (SV-AUC): Sources of Variability and Their Relative Importance

Kelly K. Arthur, John P. Gabrielson, Brent S. Kendrick, +1

Journal of Pharmaceutical Sciences

Their Relative ImportanceMedicineNatural SciencesBioanalysisMass Spectrometry +11

Precision of protein aggregation measurements by sedimentation velocity analytical ultracentrifugation in biopharmaceutical applications

John P. Gabrielson, Kelly K. Arthur, Michael R. Stoner, +8

Analytical Biochemistry

EngineeringBiochemistryNatural SciencesBioanalysisMass Spectrometry +13

Comparison of quantitative spectral similarity analysis methods for protein higher-order structure confirmation

Brandon M. Teska, Cynthia Li, Bradley C. Winn, +3

Analytical Biochemistry

BiochemistryStructural BioinformaticsProtein FoldingMedicineNatural Sciences +9

Common Excipients Impair Detection of Protein Aggregates During Sedimentation Velocity Analytical Ultracentrifugation

John P. Gabrielson, Kelly K. Arthur, Brent S. Kendrick, +2

Journal of Pharmaceutical Sciences

EngineeringMass SpectrometryField-flow FractionationDownstream ProcessingAnalytical Chemistry +7

Quantitative spectral comparison by weighted spectral difference for protein higher order structure confirmation

Nikita N Dinh, Bradley C. Winn, Kelly K. Arthur, +1

Analytical Biochemistry

BiochemistryStructural BioinformaticsProtein FoldingMedicineWeighted Spectral Difference +10

Technical Decision Making with Higher Order Structure Data: Utilization of Differential Scanning Calorimetry to Elucidate Critical Protein Structural Changes Resulting from Oxidation

Kelly K. Arthur, Nikita N Dinh, John P. Gabrielson

Journal of Pharmaceutical Sciences

Protein ChemistryBiochemistryDifferential Scanning CalorimetryProtein FoldingBiomolecular Structure Prediction +7

CHO cell production and sequence improvement in the 13C6FR1 anti-Ebola antibody

Dean K. Pettit, Richard S. Rogers, Kelly K. Arthur, +16

mAbs

ImmunodeficienciesHumoral ResponseImmunologyCho Cell ProductionImmunodominance +19

<i>In Vitro</i> Stoichiometry of Complexes between the Soluble RANK Ligand and the Monoclonal Antibody Denosumab

Kelly K. Arthur, John P. Gabrielson, Nessa Hawkins, +5

Biochemistry

Monoclonal Antibody DenosumabImmunologyBiological Mass SpectrometryQuantitative PharmacologyPeptide Science +22

Guidance to Achieve Accurate Aggregate Quantitation in Biopharmaceuticals by SV-AUC

Kelly K. Arthur, Brent S. Kendrick, John P. Gabrielson

Methods in enzymology on CD-ROM/Methods in enzymology

EngineeringSample PreparationMedicineBioanalysisMass Spectrometry +13