A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.

Jason D. Morrow, Kristina E. Hill, Raymond F. Burk, +3

Proceedings of the National Academy of Sciences

Lipid PeroxidationSecondary MetaboliteRedox BiologyFree Radical-catalyzed MechanismOxidative Stress +15

Glomerular actions of a free radical-generated novel prostaglandin, 8-epi-prostaglandin F2 alpha, in the rat. Evidence for interaction with thromboxane A2 receptors.

Kiyohiko Takahashi, Tarek Nammour, Masao Fukunaga, +5

Journal of Clinical Investigation

Antioxidant TherapyThromboxane A2 ReceptorsGlomerular ActionsInflammationMolecular Pharmacology +14

Mesangial cell, glomerular and renal vascular responses to endothelin in the rat kidney. Elucidation of signal transduction pathways.

K F Badr, John Murray, Matthew D. Breyer, +3

Journal of Clinical Investigation

Signal Transduction PathwaysRenal PathologyBiomedical EngineeringMesangial CellCellular Physiology +14

Formation of novel non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity. An animal model of lipid peroxidation.

Jason D. Morrow, Joseph Awad, Tatsuko Kato, +4

Journal of Clinical Investigation

Lipid PeroxidationRedox BiologyPolyphenolicsOxidative StressVivo Formation +16

Free radical-induced generation of isoprostanes in vivo. Evidence for the formation of D-ring and E-ring isoprostanes.

Jason D. Morrow, Tanya A. Minton, C.R. Mukundan, +6

Journal of Biological Chemistry

Evidence for the existence of F2-isoprostane receptors on rat vascular smooth muscle cells

Masao Fukunaga, Naomasa Makita, L. Jackson Roberts, +3

American Journal of Physiology-Cell Physiology

F2-isoprostane ReceptorsReceptor AntagonistPharmacotherapyCardiovascular FunctionVascular Smooth Muscle +16

Role for intrarenal mechanisms in the impaired salt excretion of experimental nephrotic syndrome.

Iekuni Ichikawa, Helmut G. Rennke, John R. Hoyer, +5

Journal of Clinical Investigation

Impaired Salt ExcretionElectrolyte DisorderRenal Salt RetentionRenal PathologyRenal Inflammation +21

Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes.

George M. Nassar, Jason D. Morrow, Lisa Roberts, +2

Journal of Biological Chemistry

InflammationIl-13 BiologyCytokineHuman Blood MonocytesFatty Acids +12

Lipoxin A4 antagonizes cellular and in vivo actions of leukotriene D4 in rat glomerular mesangial cells: evidence for competition at a common receptor.

K F Badr, David K. DeBoer, Mori Schwartzberg, +1

Proceedings of the National Academy of Sciences

Ltd4 Receptor AntagonistLipid PeroxidationImmunologyNm Lxa4Lipoxin A4 +20

Renal and systemic hemodynamic responses to intravenous infusion of leukotriene C4 in the rat.

K F Badr, Christine Baylis, J M Pfeffer, +6

Circulation Research

HypertensionImmunologyRenal InflammationLeukotriene C4Inflammation +14