A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses.

Seung Yong Hwang, Paul J. Hertzog, K.A. Holland, +6

Proceedings of the National Academy of Sciences

Viral ImmunityViral PathogenesisImmunologyPathologyImmunologic Mechanism +19

The State of Innovation in Drug Development

I. Kola

Clinical Pharmacology & Therapeutics

Pharmaceutical InnovationDrug ResistanceDrug DesignPharmaceutical PracticeIntellectual Property +16

Phenotypic characterization of an alpha 4 neuronal nicotinic acetylcholine receptor subunit knock-out mouse.

Shelley Ross, J Wong, Jeremiah J. Clifford, +8

PubMed

Synaptic TransmissionNeurotransmitterSocial SciencesMotor ActivityNicotine +20

The Ets1 transcription factor is widely expressed during murine embryo development and is associated with mesodermal cells involved in morphogenetic processes such as organ formation.

I. Kola, Sharon Brookes, Anthony R. Green, +4

Proceedings of the National Academy of Sciences

GeneticsOrgan DevelopmentCell DifferentiationEmbryologyTranscriptional Regulation +18

Centrioles in the beginning of human development.

A. Henry Sathananthan, I. Kola, J. Osborne, +4

Proceedings of the National Academy of Sciences

OocyteFertilityGeneticsDouble CentriolesOrgan Development +16

Response of a primary human fibroblast cell line to H2O2: senescence-like growth arrest or apoptosis?

Cécile Bladier, Ernst J. Wolvetang, Paul Hutchinson, +2

PubMed

Developmental BiologyApoptosisHydrogen PeroxideH2o2 ConcentrationCell Death +12

ETS1, NFκB and AP1 synergistically transactivate the human GM – CSF promoter

Ross S. Thomas, Martin J. Tymms, Leigh H McKinlay, +3

Oncogene

Transcriptional RegulationSignal TransductionSignaling PathwayMolecular RegulationGenetics +7

Cu/Zn-superoxide dismutase and glutathione peroxidase during aging.

Judy B. de Haan, Francesca Cristiano, R. C. Iannello, +1

PubMed

AgingLipid PeroxidationLipid DamageBiogerontologyAntioxidant Enzymes +14

The “gene dosage effect” hypothesis versus the “amplified developmental instability” hypothesis in Down syndrome

Melanie Pritchard, I. Kola

An association between chromosomal abnormalities in rapidly frozen 2-cell mouse embryos and the ice-forming properties of the cryoprotective solution

J. Shaw, I. Kola, Douglas R. MacFarlane, +1

Reproduction