Ian R. Graham

Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study

Maria Kinali, Virginia Arechavala‐Gomeza, Lucy Feng et al. · The Lancet Neurology · 2009 · 639 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Effects of RNA secondary structure on alternative splicing of Pre-mRNA: Is folding limited to a region behind the transcribing RNA polymerase?

Lucy P. Eperon, Ian R. Graham, Andrew D. Griffiths et al. · Cell · 1988 · 287 citations

Life Sciences, Genetics, Molecular Biology +14

Comparative Analysis of Antisense Oligonucleotide Sequences for Targeted Skipping of Exon 51 During Dystrophin Pre-mRNA Splicing in Human Muscle

Virginia Arechavala‐Gomeza, Ian R. Graham, Linda Popplewell et al. · Human Gene Therapy · 2007 · 151 citations · Full text

Life Sciences, Genetics, Molecular Biology +14

Codon and mRNA Sequence Optimization of Microdystrophin Transgenes Improves Expression and Physiological Outcome in Dystrophic mdx Mice Following AAV2/8 Gene Transfer

Helen Foster, Paul Sharp, Takis Athanasopoulos et al. · Molecular Therapy · 2008 · 115 citations · Full text

Pharmacy, Biotechnology, Molecular Biology +17

Chronic Systemic Therapy With Low-dose Morpholino Oligomers Ameliorates the Pathology and Normalizes Locomotor Behavior in mdx Mice

Alberto Malerba, Paul Sharp, Ian R. Graham et al. · Molecular Therapy · 2010 · 95 citations · Full text

Medicine, Molecular Medicine, Pharmacology +13