Association of maternal killer-cell immunoglobulin-like receptors and parental HLA-C genotypes with recurrent miscarriage

S.E. Hiby, L. Regan, Winnie Lo, +3

Human Reproduction

Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories

Renea A. Taylor, Michael Fraser, Julie Livingstone, +25

Nature Communications

A Prostate Cancer “ Nimbosus ”: Genomic Instability and SChLAP1 Dysregulation Underpin Aggression of Intraductal and Cribriform Subpathologies

Melvin L.K. Chua, Winnie Lo, Melania Pintilie, +27

European Urology

UrologyMedicinePathologyCancer GenomicsCribriform Subpathologies +5

The clinical utility of integrative genomics in childhood cancer extends beyond targetable mutations

Anita Villani, Scott Davidson, Nisha Kanwar, +48

Nature Cancer

EngineeringSickkids Cancer SequencingPathologyIntegrative GenomicsTumor Heterogeneity +14

The effect of body mass index on the outcome of pregnancy in women with recurrent miscarriage

AhlamA Al-Ghamdi, Winnie Lo, Raj Rai, +3

Journal of Family and Community Medicine

Involvement and targeted intervention of dysregulated Hedgehog signaling in osteosarcoma

Winnie Lo, Jay S. Wunder, Brendan C. Dickson, +4

Cancer

Aberrant Hedgehog Signaling and Clinical Outcome in Osteosarcoma

Winnie Lo, Dushanthi Pinnaduwage, Nalan Gökgöz, +2

Sarcoma

Aberrant Hedgehog SignalingOsteosarcoma Clinical CharacteristicsBone Morphogenic ProteinHigher LevelsMedicine +8

mTOR Inhibitors as a New Therapeutic Strategy in Treatment Resistant Epilepsy in Hemimegalencephaly: A Case Report

Qi Xu, Shimrit Uliel‐Sibony, Christopher Dunham, +9

Journal of Child Neurology

Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade

Douglas C. Palmer, Beau R. Webber, Yogin Patel, +35

Internal CheckpointTil SenescenceImmunologyImmune RegulationImmunoediting +18

333 Targeting the apical intracellular checkpoint CISH unleashes T cell neoantigen reactivity and effector program

Douglas C. Palmer, Beau R. Webber, Yogin Patel, +35

Regular and Young Investigator Award Abstracts

ImmunologyImmunoeditingImmunotherapeuticsImmune Cell TherapyCancer Biology +16