Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification

Yi-Yu Ke, Vivek Kumar Singh, Mohane Selvaraj Coumar, +9

Scientific Reports

Phenyl Benzenesulfonylhydrazides Exhibit Selective Indoleamine 2,3-Dioxygenase Inhibition with Potent <i>in Vivo</i> Pharmacodynamic Activity and Antitumor Efficacy

Shu‐Yu Lin, Teng-Kuang Yeh, Ching‐Chuan Kuo, +20

Journal of Medicinal Chemistry

Tryptophan MetabolismMedicinal ChemistryBiochemistryTumor Growth DelayMedicine +10

Synthesis and Biological Activities of 2-Amino-1-arylidenamino Imidazoles as Orally Active Anticancer Agents

Wen-Tai Li, Der-Ren Hwang, Jen-Shin Song, +15

Journal of Medicinal Chemistry

Vivo Anticancer ActivitiesMedicinal ChemistryBiochemistryMedicineNatural Sciences +12

Pharmacological Induction of Human Fetal Globin Gene in Hydroxyurea-Resistant Primary Adult Erythroid Cells

Yu‐Chi Chou, Ruei-Lin Chen, Zheng-Sheng Lai, +3

Molecular and Cellular Biology

Blood CellTranslational PharmacologyOxidative StressSystems PharmacologyMolecular Pharmacology +15

Characterization of an efficient dengue virus replicon for development of assays of discovery of small molecules against dengue virus

Chi-Chen Yang, Ming‐Han Tsai, Han-Shu Hu, +7

Antiviral Research

Dengue VirusNatural SciencesBioanalysisAntiviral Drug DevelopmentMolecular Biology +7

Function-Oriented Development of CXCR4 Antagonists as Selective Human Immunodeficiency Virus (HIV)-1 Entry Inhibitors

Chien-Huang Wu, Chuan-Jen Wang, Chun-Ping Chang, +18

Journal of Medicinal Chemistry

Marketed Cxcr4 AntagonistImmunologyImmunotherapeuticsCd4 T Cell ResponsesAntiviral Drug +15

Dual inhibition of topoisomerase I and tubulin polymerization by BPR0Y007, a novel cytotoxic agent

Jang‐Yang Chang, Hsing‐Pang Hsieh, Wen-Yu Pan, +5

Biochemical Pharmacology

Medicinal ChemistryNovel Cytotoxic AgentDual InhibitionMedicineNatural Sciences +6

Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, <i>in vitro</i> and <i>in vivo</i> evaluation

Yung Chang Hsu, Mohane Selvaraj Coumar, Wen-Chieh Wang, +22

Oncotarget

Ligand efficiency based approach for efficient virtual screening of compound libraries

Yi-Yu Ke, Mohane Selvaraj Coumar, Hui-Yi Shiao, +9

European Journal of Medicinal Chemistry

Bioorganic ChemistryLigand EfficiencyOrganic ChemistryChemistryMedicinal Chemistry +14

Antiangiogenic activities and cisplatin-combined antitumor activities of BPR0L075.

Ching-Ping Chen, Chih-Bo Hu, Kai‐Chia Yeh, +14

PubMed