Time-programmed dual release formulation by multilayered drug-loaded nanofiber meshes

Tatsuya Okuda, Kengo Tominaga, Satoru Kidoaki

Journal of Controlled Release

NanomedicineEngineeringNano-drug DeliveryBiomedical EngineeringDrug Delivery System +1

In Vitro Gene Transfection Using Dendritic Poly(<scp>l</scp>-lysine)

Mio Ohsaki, Tatsuya Okuda, Akihiro Wada, +3

Bioconjugate Chemistry

EngineeringIn Vivo Gene TherapyMolecular BiologyGene DeliveryDendritic Poly +14

Characters of dendritic poly(l-lysine) analogues with the terminal lysines replaced with arginines and histidines as gene carriers in vitro

Tatsuya Okuda, Akiko Sugiyama, Takuro Niidome, +1

Biomaterials

Dendritic PolyTerminal LysinesMedicineImmunologyGene Carriers +6

PEGylated lysine dendrimers for tumor-selective targeting after intravenous injection in tumor-bearing mice

Tatsuya Okuda, Shigeru Kawakami, Naomi Akimoto, +3

Journal of Controlled Release

Drug TargetingTumor-selective TargetingMedicinePolymer-drug ConjugateTumor Targeting +7

Biodistribution characteristics of amino acid dendrimers and their PEGylated derivatives after intravenous administration

Tatsuya Okuda, Shigeru Kawakami, Tadahiro Maeie, +3

Journal of Controlled Release

Medicinal ChemistryPharmaceutical ScienceIntravenous AdministrationBiochemistryMedicine +8

Novel histidine-conjugated galactosylated cationic liposomes for efficient hepatocyte-selective gene transfer in human hepatoma HepG2 cells

Kosuke Shigeta, Shigeru Kawakami, Yuriko Higuchi, +4

Journal of Controlled Release

Cell-based Drug DeliveryHepatologyBiochemistryCationic LiposomesLiver Physiology +5

Long circulation of intravenously administered plasmid DNA delivered with dendritic poly(l-lysine) in the blood flow

Takahito Kawano, Tatsuya Okuda, Haruhiko Aoyagi, +1

Journal of Controlled Release

Translational MedicineNatural SciencesHematologyMolecular BiologyDna Replication +6

Time-dependent complex formation of dendritic poly(L-lysine) with plasmid DNA and correlation with in vitro transfection efficiencies

Tatsuya Okuda, Satoru Kidoaki, Mio Ohsaki, +4

Organic & Biomolecular Chemistry

Gangliosides Act as Co-receptors for Salmonella enteritidis FliC and Promote FliC Induction of Human β-Defensin-2 Expression in Caco-2 Cells

Ken-ichi Ogushi, Akihiro Wada, Takuro Niidome, +9

Journal of Biological Chemistry

Cytosolic soluble proteins induce DNA release from DNA–gene carrier complexes

Tatsuya Okuda, Takuro Niidome, Haruhiko Aoyagi

Journal of Controlled Release

Natural SciencesDna ReplicationMolecular BiologyGene DeliveryMedicine +4