CJ-023,423, a Novel, Potent and Selective Prostaglandin EP4 Receptor Antagonist with Antihyperalgesic Properties

Kazunari Nakao, Akio Murase, Hiroyuki Ohshiro, +7

Journal of Pharmacology and Experimental Therapeutics

(<i>S</i>)-β,ω-Dihydroxyalkyl Phenyl Sulfones. Synthesis by Bakers Yeast Reduction and Use as Precursors of Optically Active Lactones

Toshio Sato, Yoshiyuki Okumura, Junichi Itai, +1

Chemistry Letters

EngineeringBiochemistryBakers Yeast ReductionNatural SciencesOptically Active Lactones +12

Novel imidazole compounds as a new series of potent, orally active inhibitors of 5-lipoxygenase

Takashi Mano, Rodney W. Stevens, Kazuo Ando, +6

Bioorganic & Medicinal Chemistry

Novel Imidazole CompoundsMedicinal ChemistryBiochemistryMedicineActive Inhibitors +9

4-[5-Fluoro-3-[4-(2-methyl-1<i>H</i>-imidazol-1-yl)benzyloxy]phenyl]-3,4,5,6- tetrahydro-2<i>H</i>-pyran-4-carboxamide, an Orally Active Inhibitor of 5-Lipoxygenase with Improved Pharmacokinetic and Toxicology Characteristics

Takashi Mano, Yoshiyuki Okumura, Minoru Sakakibara, +4

Journal of Medicinal Chemistry

Pharmaceutical SciencePharmacotherapyPharmaceutical ChemistryOxidative StressMolecular Pharmacology +16

Elastase and elastase inhibitor from Aspergillus fumigatus, Aspergillus flavus and Aspergillus niger

Yoshiyuki Okumura, Kenji Ogawa, Toshiaki Nikai

Journal of Medical Microbiology

Industrial MycologyAntifungal AgentElastase Inhibitory ActivityBiochemistryAspergillus Fumigatus +10

Characterization and Primary Structure of Elastase Inhibitor, AFLEI from Aspergillus flavus

Yoshiyuki Okumura, Kenji Ogawa, Kei‐ichi Uchiya, +1

Nippon Ishinkin Gakkai Zasshi

Industrial MycologyWeak Inhibitory ActivityAntifungal AgentBiochemistryPrimary Structure +12

Optimization of Imidazole 5-Lipoxygenase Inhibitors and Selection and Synthesis of a Development Candidate

Takashi Mano, Rodney W. Stevens, Kazuo Ando, +8

Chemical and Pharmaceutical Bulletin

Combinatorial ChemistryMedicinal ChemistryImidazole 5-Lipoxygenase InhibitorsBioorganic ChemistryBiochemistry +12

Photochemical Deracemization of a Medicinally‐Relevant Benzopyran using an Oscillatory Flow Reactor

Jason D. Williams, Peter Pöchlauer, Yoshiyuki Okumura, +2

Chemistry - A European Journal

EngineeringBatch CrystallizationSynthetic PhotochemistryOrganic ChemistryChemistry +16

Biochemical properties and primary structure of elastase inhibitor AFUEI from Aspergillus fumigatus

Yoshiyuki Okumura, Takeshi Matsui, Kenji Ogawa, +2

Journal of Medical Microbiology

Antifungal AgentElastase Inhibitory ActivityEngineeringBiochemistryAspergillus Fumigatus +10

Biological properties of elastase inhibitor, AFLEI from Aspergillus flavus

Yoshiyuki Okumura, Kenji Ogawa, Kei‐ichi Uchiya, +3

Nippon Ishinkin Gakkai Zasshi

Industrial MycologyCasamino AcidAntifungal AgentBiochemistryAntifungal Agents +10