Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein

Marcus Järås, Petra Johnels, Nils Hansen, +8

Proceedings of the National Academy of Sciences

Selective killing of candidate AML stem cells by antibody targeting of IL1RAP

Maria Askmyr, Helena Ågerstam, Nils Hansen, +7

Blood

Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia

Helena Ågerstam, Christine Karlsson, Nils Hansen, +13

Proceedings of the National Academy of Sciences

IL1RAP antibodies block IL-1–induced expansion of candidate CML stem cells and mediate cell killing in xenograft models

Helena Ågerstam, Nils Hansen, Sofia von Palffy, +14

Blood

JAK2-mutant hematopoietic cells display metabolic alterations that can be targeted to treat myeloproliferative neoplasms

Tata Nageswara Rao, Nils Hansen, Julian Hilfiker, +27

Blood

Inhibition of interleukin-1β reduces myelofibrosis and osteosclerosis in mice with JAK2-V617F driven myeloproliferative neoplasm

Shivam Rai, Élodie Grockowiak, Nils Hansen, +8

Nature Communications

<i>JAK2</i>-V617F and interferon-α induce megakaryocyte-biased stem cells characterized by decreased long-term functionality

Tata Nageswara Rao, Nils Hansen, Jan Stetka, +16

Blood

IL-1β promotes MPN disease initiation by favoring early clonal expansion of <i>JAK2</i>-mutant hematopoietic stem cells

Shivam Rai, Yang Zhang, Élodie Grockowiak, +14

Blood Advances

Interleukin 1β, tumor necrosis factor-α and interleukin 6 decrease nuclear thyroid hormone receptor capacity in a liver cell line

Matthias Wolf, Nils Hansen, H. Greten

European Journal of Endocrinology

Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice

Helena Ågerstam, Marcus Järås, Anna Andersson, +10

Blood