Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis

Alasdair Coles, Mark Wing, Paul Molyneux, +6

Annals of Neurology

Neurological DisorderImmunologyImmunotherapyMagnetic Resonance ImagingNeuroinflammation +18

Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis

Alasdair Coles, Mark Wing, Sheila I. Smith, +8

The Lancet

Autoimmune DiseaseNeurological DisorderMedicineImmunologyAutoimmune Thyroid Disease +7

Mechanism of first-dose cytokine-release syndrome by CAMPATH 1-H: involvement of CD16 (FcgammaRIII) and CD11a/CD18 (LFA-1) on NK cells.

Mark Wing, T. Moreau, Judith Greenwood, +6

Journal of Clinical Investigation

First-dose Cytokine-release SyndromeImmunologyImmune RegulationNk CellsImmunologic Mechanism +15

Transient increase in symptoms associated with cytokine release in patients with multiple sclerosis

Thibault Moreau, Alasdair Coles, Mark Wing, +4

Brain

Neurological DisorderImmunologyImmune RegulationPathologyImmunologic Mechanism +17

Preliminary evidence from magnetic resonance imaging for reduction in disease activity after lymphocyte depletion in multiple sclerosis

T. Moreau, Neil Scolding, Alastair Compston, +8

The Lancet

Autoimmune DiseaseDisease ProgressionNeurological DisorderMedicineResonance +9

INTERACTIONS BETWEEN OLIGODENDROCYTES AND MICROGLIA

John Zajicek, Mark Wing, Neil Scolding, +1

Brain

Fully human, HLA-DR-specific monoclonal antibodies efficiently induce programmed death of malignant lymphoid cells

Zoltan A. Nagy, Bernd Hubner, Corinna Löhning, +17

Nature Medicine

Lymphoid NeoplasiaHla-dr-specific Monoclonal AntibodiesProgrammed DeathMalignant Lymphoid CellsMalignant Blood Disorder +8

INTERACTIONS BETWEEN OLIGODENDROCYTES AND MICROGLIA

John Zajicek, Mark Wing, Neil Scolding, +1

Brain

Lung InflammationInnate Immune SystemImmune RegulationImmunologyPathology +23

Nonactivated microglia promote oligodendrocyte precursor survival and maturation through the transcription factor NF‐κB

Richard Nicholas, Mark Wing, Alastair Compston

European Journal of Neuroscience

Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosis

Berend Isermann, Sara B. Hendrickson, Mark Zogg, +5

Journal of Clinical Investigation

Juvenile-onset ThrombosisImmunologyPathologyCell DeathInflammation +21