Metabolic Regulation by the Mitochondrial Phosphatase PTPMT1 Is Required for Hematopoietic Stem Cell Differentiation

Wen-Mei Yu, Xia Liu, Jinhua Shen, +6

Cell stem cell

Developmental BiologyMitochondrial FunctionMedicineMetabolic RegulationMetabolic Remodeling +7

The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer

Lingtao Jin, Jaemoo Chun, Chaoyun Pan, +14

Molecular Cell

Tumor BiologySignaling PathwayMedicineReceptor Tyrosine KinaseAutophagy +10

Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment

Lei Dong, Wen-Mei Yu, Hong Zheng, +8

Nature

Lineage PlasticityDevelopmental BiologyCell RegulationCell SpecializationMedicine +8

Factor XII and uPAR upregulate neutrophil functions to influence wound healing

Evi X. Stavrou, Chao Fang, Kara L. Bane, +20

Journal of Clinical Investigation

Inflammatory Lung DiseaseLung InflammationInnate Immune SystemImmunologyRenal Inflammation +23

Biased Suppression of Hematopoiesis and Multiple Developmental Defects in Chimeric Mice Containing Shp-2 Mutant Cells

Cheng‐Kui Qu, Wen-Mei Yu, Biagio Azzarelli, +3

Molecular and Cellular Biology

Non–lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase <i>Ptpn11</i> (Shp2) on malignant transformation of hematopoietic cells

Dan Xu, Xia Liu, Wen-Mei Yu, +4

The Journal of Experimental Medicine

Mixed-phenotype Acute LeukemiaImmunologyTumor BiologyCentrosome AmplificationMyeloid Neoplasia +24

Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca2+ homeostasis

Jinhua Shen, Wen-Mei Yu, Marco Brotto, +6

Nature Cell Biology

Ca2+ HomeostasisMuscle DisorderMuscle FunctionMolecular PhysiologySignal Transduction +10

Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals

Cheng‐Kui Qu, Wen-Mei Yu, Biagio Azzarelli, +1

Proceedings of the National Academy of Sciences

Critical role of ASCT2-mediated amino acid metabolism in promoting leukaemia development and progression

Fang Ni, Wen-Mei Yu, Zhiguo Li, +7

Nature Metabolism

BiochemistryOncogenic AgentMedicineCritical RoleNatural Sciences +6

Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism

Xia Liu, Hong Zheng, Wen-Mei Yu, +3

Blood