Yaohui Chai

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70

John M. Warrick, Ho Yin Edwin Chan, Gladys L. Gray-Board et al. · Nature Genetics · 1999 · 832 citations

Neurodegenerative Diseases, Molecular Neuroscience, Genetics +8

Analysis of the Role of Heat Shock Protein (Hsp) Molecular Chaperones in Polyglutamine Disease

Yaohui Chai, Stacia L. Koppenhafer, Nancy M. Bonini et al. · Journal of Neuroscience · 1999 · 428 citations · Full text

Molecular Biology, Protein Folding, Experimental Neuropathology +17

Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis

Yaohui Chai, Jianqiang Shao, Victor M. Miller et al. · Proceedings of the National Academy of Sciences · 2002 · 203 citations · Full text

Engineering, Molecular Biology, Polyglutamine Protein Kinetics +18

Poly-ubiquitin Binding by the Polyglutamine Disease Protein Ataxin-3 Links Its Normal Function to Protein Surveillance Pathways

Yaohui Chai, Sarah Shoesmith Berke, Robert E. Cohen et al. · Journal of Biological Chemistry · 2004 · 170 citations · Full text

A Homozygous Microdeletion in Helix 7 of the Luteinizing Hormone Receptor Associated with Familial Testicular and Ovarian Resistance Is Due to Both Decreased Cell Surface Expression and Impaired Effector Activation by the Cell Surface Receptor

Ana Cláudia Latronico, Yaohui Chai, Ivo J.P. Arnhold et al. · Molecular Endocrinology · 1998 · 122 citations · Full text