Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70

John M. Warrick, Ho Yin Edwin Chan, Gladys L. Gray-Board, +3

Nature Genetics

Neurodegenerative DiseasesMolecular NeuroscienceGeneticsMolecular Chaperone Hsp70Chaperones +6

Analysis of the Role of Heat Shock Protein (Hsp) Molecular Chaperones in Polyglutamine Disease

Yaohui Chai, Stacia L. Koppenhafer, Nancy M. Bonini, +1

Journal of Neuroscience

Molecular BiologyProtein FoldingExperimental NeuropathologyDegenerative PathologyChaperones +15

Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis

Yaohui Chai, Jianqiang Shao, Victor M. Miller, +2

Proceedings of the National Academy of Sciences

EngineeringMolecular BiologyPolyglutamine Protein KineticsOptogeneticsCell Imaging +16

Poly-ubiquitin Binding by the Polyglutamine Disease Protein Ataxin-3 Links Its Normal Function to Protein Surveillance Pathways

Yaohui Chai, Sarah Shoesmith Berke, Robert E. Cohen, +1

Journal of Biological Chemistry

A Homozygous Microdeletion in Helix 7 of the Luteinizing Hormone Receptor Associated with Familial Testicular and Ovarian Resistance Is Due to Both Decreased Cell Surface Expression and Impaired Effector Activation by the Cell Surface Receptor

Ana Cláudia Latronico, Yaohui Chai, Ivo J.P. Arnhold, +3

Molecular Endocrinology

The Role of Protein Composition in Specifying Nuclear Inclusion Formation in Polyglutamine Disease

Yaohui Chai, Lizi Wu, James D. Griffin, +1

Journal of Biological Chemistry

Neurodegenerative DiseasesProtein FunctionProtein CompositionDisease MechanismNatural Sciences +13

Defining the Role of Ubiquitin-interacting Motifs in the Polyglutamine Disease Protein, Ataxin-3

Sarah J Shoesmith Berke, Yaohui Chai, Ginger L. Marrs, +2

Journal of Biological Chemistry

Ubiquitin Interaction MotifsImmunologyMolecular BiologyPolyglutamine Disease ProteinProtein Misfolding +16

Association of Gonadotropin Receptor Precursors with the Protein Folding Chaperone Calnexin¹

Tim G. Rozell, David P. Davis, Yaohui Chai, +1

Endocrinology

Proteinlipid InteractionGlycobiologyMolecular BiologyFsh ReceptorsProtein Folding +20

Hereditary inclusion‐body myopathy associated with cardiomyopathy: Report of two siblings

Yaohui Chai, Tulio E. Bertorini, Frank McGrew

Muscle & Nerve

Limb edema and anasarca associated with severe dermatomyositis: Report of four cases

Yaohui Chai, Tulio E. Bertorini, Yingjun D. Li, +2

Neuromuscular Disorders

Severe DermatomyositisDermatologyDermatopathologyMedicineLimb Edema