The ligands/activators for peroxisome proliferator-activated receptor  α (PPARα) and PPARγ increase Cu2+, Zn2+-superoxide dismutase and decrease p22phox message expressions in primary endothelial cells

Ikuo Inoue, Seiichi Goto, Toshiyuki Matsunaga, +5

Metabolism

InflammationRedox SignalingBiochemistryCell SignalingPhysiology +9

Alkaline phosphatases reduce toxicity of lipopolysaccharides in vivo and in vitro through dephosphorylation

Iwao Koyama, Toshiyuki Matsunaga, Tsuyoshi Harada, +2

Clinical Biochemistry

OxysterolBiochemistryMedicineNatural SciencesCell Death +6

CLOCK/BMAL1 is Involved in Lipid Metabolism via Transactivation of the Peroxisome Proliferator-activated Receptor (PPAR) Response Element

Ikuo Inoue, Yuichi Shinoda, Masaaki Ikeda, +9

Journal of Atherosclerosis and Thrombosis

ChronobiologyLipid SynthesisLipid MetabolismBiochemistryMedicine +12

Bezafibrate has an antioxidant effect: Peroxisome proliferator-activated receptor α is associated with Cu2+, Zn2+-superoxide dismutase in the liver

Ikuo Inoue, Satoru Noji, Takuya Awata, +5

Life Sciences

InflammationRedox SignalingAntioxidant EffectMedicineLiver Physiology +12

Clostridium Butyricum MIYAIRI 588 Improves High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats

Makoto Seo, Ikuo Inoue, Mamoru Tanaka, +6

Digestive Diseases and Sciences

ObesityMetabolic SyndromeNutritionHepatologyLipid Nutrition +7

Troglitazone Has a Scavenging Effect on Reactive Oxygen Species

Ikuo Inoue, Shigehiro Katayama, Keiichi Takahashi, +4

Biochemical and Biophysical Research Communications

BiochemistryMedicinePharmacologyReactive Oxygen SpecieReactive Oxygen Species +2

Human tissue non-specific alkaline phosphatases: sugar-moiety-induced enzymic and antigenic modulations and genetic aspects

Olivier Nosjean, Iwao Koyama, Masae Goseki, +2

Biochemical Journal

The mechanism of elevated alkaline phosphatase activity after bile duct ligation in the rat

Shakuntla Seetharam, Norman Sussman, Tsugikazu Komoda, +1

Hepatology

CholangiopathiesBile Duct LigationProtein SynthesisProtein ExpressionBiliary Disorder +14

NF- activation in endothelial cells treated with oxidized high-density lipoprotein

Toshiyuki Matsunaga, Shigeru Hokari, Iwao Koyama, +2

Biochemical and Biophysical Research Communications

InflammationEndothelial CellsBiochemistryCell SignalingMedicine +12

The function of carbohydrate moiety and alteration of carbohydrate composition in human alkaline phosphatase isoenzymes

Tsugikazu Komoda, Yoshikatsu Sakagishi

Biochimica et Biophysica Acta (BBA) - Enzymology

Energy MetabolismAldo-keto ReductaseCellular EnzymologyBiochemistryCarbohydrate Composition +7