High Glucose Represses β-Klotho Expression and Impairs Fibroblast Growth Factor 21 Action in Mouse Pancreatic Islets

Wing Yan So, Qianni Cheng, Lihua Chen, +4

Diabetes

Fgf21 ResistanceInsulin SignalingMetabolic SyndromeMouse Pancreatic IsletsFgf21 Signaling +18

Alk and Ltk ligands are essential for iridophore development in zebrafish mediated by the receptor tyrosine kinase Ltk

Elizabeth S. Mo, Qianni Cheng, Andrey V. Reshetnyak, +2

Proceedings of the National Academy of Sciences

Combination of the Dipeptidyl Peptidase IV Inhibitor LAF237 [(S)-1-[(3-Hydroxy-1-adamantyl)ammo]acetyl-2-cyanopyrrolidine] with the Angiotensin II Type 1 Receptor Antagonist Valsartan [N-(1-Oxopentyl)-N-[[2′-(1 H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl]methyl]-l-valine] Enhances Pancreatic Islet Morphology and Function in a Mouse Model of Type 2 Diabetes

Qianni Cheng, Pui Ki Law, Marc de Gasparo, +1

Journal of Pharmacology and Experimental Therapeutics

Targeted Inactivation of Kinesin-1 in Pancreatic β-Cells In Vivo Leads to Insulin Secretory Deficiency

Ju Cui, Zai Wang, Qianni Cheng, +7

Diabetes

Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets

Lihua Chen, Wing Yan So, Stephen Y. T. Li, +3

Molecular and Cellular Endocrinology

Molecular PharmacologyMolecular PhysiologyPancreatic IsletsBiochemistryNiacin Receptor Gpr109a +7

Angiotensin II exerts glucose-dependent effects on K_vcurrents in mouse pancreatic β-cells via angiotensin II type 2 receptors

Kwan Yi Chu, Qianni Cheng, Chen Chen, +6

American Journal of Physiology-Cell Physiology

Ang IiPancreas TransplantationCellular PhysiologyInsulin SignalingOxidative Stress +16

Insulinotropic effects of GPR120 agonists are altered in obese diabetic and obese non-diabetic states

Dan Zhang, Wing Yan So, Yi Wang, +3

Clinical Science

Gpr120 AgonistsResident Gpr120Insulin SignalingGpr120 ExpressionObesity +21

Hedgehog signaling in bone regulates whole-body energy metabolism through a bone–adipose endocrine relay mediated by PTHrP and adiponectin

Xu Zhang, Qianni Cheng, Po Sing Leung, +1

Cell Death and Differentiation

OsteoporosisBone Morphogenic ProteinBone HomeostasisMetabolic SignalingCell Signaling +14

A hypothalamic pathway for Augmentor α–controlled body weight regulation

Mansoor Ahmed, Navjot Kaur, Qianni Cheng, +5

Proceedings of the National Academy of Sciences

NeuroendocrinologyMetabolic RemodelingHypothalamic CircuitsTumor BiologyObesity +21

Human Fetal Liver Stromal Cell Co-Culture Enhances the Differentiation of Pancreatic Progenitor Cells into Islet-Like Cell Clusters

Juan Boo Liang, Ka Yan Ng, Qianni Cheng, +3

Stem Cell Reviews and Reports

Human CellDevelopmental BiologyIslet-like Cell ClustersLiver PhysiologyMedicine +6