Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

Peter Kuehl, Jiong Zhang, Yvonne Lin, +16

Nature Genetics

Cyp3a PromotersTranscriptional RegulationPlant Gene ExpressionNatural SciencesGenetics +12

Cloning and primary structure of neurocan, a developmentally regulated, aggregating chondroitin sulfate proteoglycan of brain.

Uwe Rauch, Laina Karthikeyan, P Maurel, +2

Journal of Biological Chemistry

Chondroitin Sulfate ProteoglycanGlycobiologyMolecular BiologyCellular NeurobiologyCellular Physiology +18

Induction of CYP2C genes in human hepatocytes in primary culture.

Sabine Gerbal‐Chaloin, Jean‐Marc Pascussi, Lydiane Pichard‐Garcia, +4

PubMed

ImmunologyPharmacotherapyExperimental PharmacologyCellular PhysiologyCyp2c Genes +16

Phosphacan, a chondroitin sulfate proteoglycan of brain that interacts with neurons and neural cell-adhesion molecules, is an extracellular variant of a receptor-type protein tyrosine phosphatase.

P Maurel, Uwe Rauch, Manuela Flad, +2

Proceedings of the National Academy of Sciences

Chondroitin Sulfate ProteoglycanGlycobiologyMolecular BiologyCellular PhysiologyExtracellular Variant +18

Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines.

Thomas K. H. Chang, P Maurel, David J. Waxman

PubMed

ImmunologyPharmacotherapyIfosfamide 4-HydroxylationRedox BiologyToxicological Mechanism +18

The antibiotic rifampicin is a nonsteroidal ligand and activator of the human glucocorticoid receptor

Cécile Calleja, Jean‐Marc Pascussi, J. C. Mani, +2

Nature Medicine

Health SciencesAntibioticsMedicineImmunologyAntibiotic Rifampicin +11

Calcium channel modulators of the dihydropyridine family are human pregnane X receptor activators and inducers of CYP3A, CYP2B, and CYP2C in human hepatocytes.

Lionel Drocourt, Jean‐Marc Pascussi, Eric Assénat, +3

PubMed

Calcium Channel ModulatorsCytochromes P450Cellular PharmacologyCotransfection ExperimentsCellular Physiology +16

The Fetal Specific GeneCYP3A7Is Inducible by Rifampicin in Adult Human Hepatocytes in Primary Culture

Joëlle Greuet, Lydiane Pichard, Claude Bonfils, +2

Biochemical and Biophysical Research Communications

InflammationHepatologyAdult HumanLiver PhysiologyPathogenesis +8

Cloning of a major heparan sulfate proteoglycan from brain and identification as the rat form of glypican

Laina Karthikeyan, P Maurel, Uwe Rauch, +2

Biochemical and Biophysical Research Communications

Human Hepatocytes in Primary Culture Predict Lack of Cytochrome P-450 3A4 Induction by Eletriptan In Vivo

Lydiane Pichard‐Garcia, Ruth Hyland, J.-L. Baulieu, +3

Drug Metabolism and Disposition