Pain relief produces negative reinforcement through activation of mesolimbic reward–valuation circuitry

Edita Navratilova, Jennifer Y. Xie, Alec Okun, +7

Proceedings of the National Academy of Sciences

Pain TherapyPain DisordersMesolimbic Reward–valuation CircuitryAcute PainPain Medicine +23

Lesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy

Chaoling Qu, Tamara King, Alec Okun, +3

Pain

Acute PainSpontaneous Neuropathic PainPain MedicineNeuropathic PainMolecular Pain +16

Endogenous Opioid Activity in the Anterior Cingulate Cortex Is Required for Relief of Pain

Edita Navratilova, Jennifer Y. Xie, Diana Meske, +7

Journal of Neuroscience

Kappa opioid signaling in the central nucleus of the amygdala promotes disinhibition and aversiveness of chronic neuropathic pain

Edita Navratilova, Guangchen Ji, Caroline E. Phelps, +5

Pain

Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity

Tamara King, Chaoling Qu, Alec Okun, +5

Pain

Multiple sites and actions of gabapentin-induced relief of ongoing experimental neuropathic pain

Kirsty Bannister, Chaoling Qu, Edita Navratilova, +5

Pain

CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide

Aubin Moutal, Xiaofang Yang, Wennan Li, +14

Pain

Pain MedicinePathologyNeuropathic PainMolecular PainNf1 Pain +16

Activation of mesocorticolimbic reward circuits for assessment of relief of ongoing pain: A potential biomarker of efficacy

Jennifer Y. Xie, Chaoling Qu, Amol Patwardhan, +5

Pain

Pain TherapyAcute PainPain MedicinePotential BiomarkerNeuropathic Pain +23

(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology

Aubin Moutal, Lindsey A. Chew, Xiaofang Yang, +14

Pain

Decreased dopaminergic inhibition of pyramidal neurons in anterior cingulate cortex maintains chronic neuropathic pain

Kevin Lançon, Chaoling Qu, Edita Navratilova, +2

Cell Reports

Pain SyndromeChronic Neuropathic PainHealth SciencesNeuroanatomyPain Medicine +12