R.F. Doolittle

Computer analysis of retroviral pol genes: assignment of enzymatic functions to specific sequences and homologies with nonviral enzymes.

Mark S. Johnson, Marcella A. McClure, Da-Fei Feng et al. · Proceedings of the National Academy of Sciences · 1986 · 482 citations

Viral Replication, Reverse Genetics, Computer Analysis +21

Domainal evolution of a prokaryotic DNA repair protein and its relationship to active-transport proteins

R.F. Doolittle, M. S. Johnson, Intisar Husain et al. · Nature · 1986 · 187 citations

Genome Instability, Protein Function, Natural Sciences +9

Drosophila kelch motif is derived from a common enzyme fold

Peer Bork, R.F. Doolittle · Journal of Molecular Biology · 1994 · 176 citations

Biology, Developmental Genetics, Protein Folding +10

Sequence comparisons of retroviral proteins: relative rates of change and general phylogeny.

Marcella A. McClure, Mark S. Johnson, Da-Fei Feng et al. · Proceedings of the National Academy of Sciences · 1988 · 166 citations

Reverse Genetics, Genetics, Molecular Genetics +21

A naturally occurring horizontal gene transfer from a eukaryote to a prokaryote

R.F. Doolittle, Da-Fei Feng, K. L. Anderson et al. · Journal of Molecular Evolution · 1990 · 151 citations

Biology, Unicellular Organism, Prokaryotic System +9