A quantitative analysis of kinase inhibitor selectivity

Mazen W. Karaman, Sanna Herrgård, Daniel K. Treiber, +18

Nature Biotechnology

Drug TargetSignal TransductionMedicineReceptor Tyrosine KinaseKinase Inhibitor Selectivity +4

A small molecule–kinase interaction map for clinical kinase inhibitors

Miles A. Fabian, William Biggs, Daniel K. Treiber, +23

Nature Biotechnology

Molecular DockingDrug TargetClinical Kinase InhibitorsMedicinePharmacology +2

Antitumor Activity of HKI-272, an Orally Active, Irreversible Inhibitor of the HER-2 Tyrosine Kinase

Sridhar K. Rabindran, Carolyn Discafani, Edward Rosfjord, +13

Cancer Research

Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases

Todd A. Carter, Lisa Wodicka, Neil P. Shah, +19

Proceedings of the National Academy of Sciences

Optimization of 6,7-Disubstituted-4-(arylamino)quinoline-3-carbonitriles as Orally Active, Irreversible Inhibitors of Human Epidermal Growth Factor Receptor-2 Kinase Activity

Hwei‐Ru Tsou, Elsebe G. Overbeek-Klumpers, William Hallett, +13

Journal of Medicinal Chemistry

Medicinal ChemistryBiochemistrySafer Cyclization StepMedicineNatural Sciences +11

Synthesis and Structure−Activity Relationships of 6,7-Disubstituted 4-Anilinoquinoline-3-carbonitriles. The Design of an Orally Active, Irreversible Inhibitor of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor (EGFR) and the Human Epidermal Growth Factor Receptor-2 (HER-2)

Allan Wissner, Elsebe Overbeek, Marvin F. Reich, +16

Journal of Medicinal Chemistry

Combinatorial ChemistryPharmaceutical ScienceBioorganic ChemistryPharmacotherapy6,7-Disubstituted 4-Anilinoquinoline-3-carbonitriles +17

4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile Inhibitors of Epidermal Growth Factor Receptor Kinase and Their Bioisosteric Relationship to the 4-Anilino-6,7-dialkoxyquinazoline Inhibitors

Allan Wissner, Dan M. Berger, Diane H. Boschelli, +14

Journal of Medicinal Chemistry

Pharmaceutical ScienceOrganic ChemistryPharmacotherapyDermatologyHeterocycle Chemistry +17

Prostaglandins and congeners. 20. Synthesis of prostaglandins via conjugate addition of lithium trans-1-alkenyltrialkylalanate reagents. A novel reagent for conjugate 1,4-additions

Karel F. Bernady, M. Brawner Floyd, John F. Poletto, +1

The Journal of Organic Chemistry

Novel ReagentLithium Trans-1-alkenyltrialkylalanate ReagentsAltmetric Attention ScoreOrganic ChemistrySocial Media Presence +7

The oxidation of acetophenones to arylglyoxals with aqueous hydrobromic acid in dimethyl sulfoxide

M. Brawner Floyd, Mila T. Du, Paul F. Fabio, +2

The Journal of Organic Chemistry

EngineeringChemical AnalysisAltmetric Attention ScoreOrganic ChemistryAqueous Hydrobromic Acid +15

Activation State-Dependent Binding of Small Molecule Kinase Inhibitors: Structural Insights from Biochemistry

Lisa Wodicka, Pietro Ciceri, Mindy I. Davis, +8

Chemistry & Biology

Drug TargetSignal TransductionBiochemistryStructural InsightsMedicine +10