ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

Heather Stanton, Fraser M. Rogerson, Charlotte J. East, +9

Nature

Regenerative MedicineMajor AggrecanaseDevelopmental BiologyMusculoskeletal ResearchMouse Cartilage +8

Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation

Pejman Soroosh, Jiejun Wu, Xiaohua Xue, +34

Proceedings of the National Academy of Sciences

Lipid PeroxidationImmune RegulationImmunologyInnate ImmunityRedox Biology +24

Catalytic Activity of ADAM8, ADAM15, and MDC-L (ADAM28) on Synthetic Peptide Substrates and in Ectodomain Cleavage of CD23

Anne M. Fourie, Fawn Coles, Veronica Moreno, +1

Journal of Biological Chemistry

Impaired Immunoproteasome Assembly and Immune Responses in <i> PA28 ^−/− </i> Mice

Tobias Preckel, Wai‐Ping Fung‐Leung, Zeling Cai, +15

Science

RORγt and RORα signature genes in human Th17 cells

Glenda Castro, Xuejun Liu, Karen Ngo, +13

PLoS ONE

Global Gene ExpressionLymphocyte DevelopmentGeneticsImmune RegulationImmunology +20

Single-cell RNA sequencing of psoriatic skin identifies pathogenic Tc17 cell subsets and reveals distinctions between CD8+ T cells in autoimmunity and cancer

Jared Liu, Hsin-Wen Chang, Zhiming Huang, +18

Journal of Allergy and Clinical Immunology

Single-cell Rna SequencingAutoimmune DiseaseTc17 Cell SubsetsMedicineT-regulatory Cell +8

Leukotriene B4 Receptors BLT1 and BLT2: Expression and Function in Human and Murine Mast Cells

Katherine A. Lundeen, Binggang Sun, Lars Karlsson, +1

The Journal of Immunology

Expression and Regulation of the Metalloproteinase ADAM-8 during Human Neutrophil Pathophysiological Activation and Its Catalytic Activity on L-Selectin Shedding

María Victoria Gómez‐Gaviro, María Jesús Domínguez‐Luis, Javier Canchado, +9

The Journal of Immunology

IL-23 past, present, and future: a roadmap to advancing IL-23 science and therapy

James G. Krueger, Kilian Eyerich, Vijay K. Kuchroo, +9

Frontiers in Immunology

Anti-Inflammatory Activity of a Potent, Selective Leukotriene A4 Hydrolase Inhibitor in Comparison with the 5-Lipoxygenase Inhibitor Zileuton

Navin Rao, Paul J. Dunford, Xiaohua Xue, +9

Journal of Pharmacology and Experimental Therapeutics