Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions

Peter Carmeliet, Lieve Moons, Aernout Luttun, +26

Nature Medicine

Developmental BiologyAngiogenesisPlacental Growth FactorEndothelial DysfunctionGynecology +9

Anti-PlGF Inhibits Growth of VEGF(R)-Inhibitor-Resistant Tumors without Affecting Healthy Vessels

Christian Fischer, Bart Jonckx, Massimiliano Mazzone, +17

Cell

Tumor BiologyAngiogenesisMedicinePharmacologyPathology +8

Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1

Monica Autiero, Johannes Waltenberger, Didier Communi, +24

Nature Medicine

Developmental BiologyAngiogenesisSignal TransductionTumor MicroenvironmentSignaling Pathway +8

HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PlGF

Charlotte Rolny, Massimiliano Mazzone, Sònia Tugues, +24

Cancer Cell

AngiogenesisImmunologyCell ProliferationVascular BiologyVessel Normalization +8

Further Pharmacological and Genetic Evidence for the Efficacy of PlGF Inhibition in Cancer and Eye Disease

Sara Van de Veire, Ingeborg Stalmans, Femke Heindryckx, +48

Cell

Ocular DiseaseEye DiseaseOphthalmologyPlgf InhibitionMedicine +5

Loss or Inhibition of Stromal-Derived PlGF Prolongs Survival of Mice with Imatinib-Resistant Bcr-Abl1+ Leukemia

Thomas Schmidt, Behzad Kharabi Masouleh, Sonja Loges, +25

Cancer Cell

Hematological MalignancyImatinib-resistant Bcr-abl1+ LeukemiaImmunologyMedicineCell Biology +3

Purification and characterization of natural and recombinant human plasminogen activator inhibitor‐1 (PAI‐1)

Marie‐Christine Alessi, Paul Declerck, Maria De Mol, +2

European Journal of Biochemistry

Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells

Marc Tjwa, Nicolai Sidénius, Rute Moura, +9

Journal of Clinical Investigation

Induced Pluripotent Stem CellDevelopmental BiologyUrokinase ReceptorCell DivisionHspc Proliferation +13

Reactivated Recombinant Plasminogen Activator Inhibitor-1 (rPAI-1) Effectively Prevents Thrombolysis In Vivo

Douglas E. Vaughan, Paul Declerck, E Van Houtte, +2

Thrombosis and Haemostasis

ThrombopoiesisThrombosisVenous ThrombosisCardiovascular DiseaseReactivated Human Rpai-1 +13

Targeted Deletion of the Cytosolic Domain of Tissue Factor in Mice Does Not Affect Development

Els Melis, Lieve Moons, Maria De Mol, +5

Biochemical and Biophysical Research Communications

Knockout MouseLineage PlasticityDevelopmental BiologyTissue DevelopmentCytosolic Domain +8