Jan-Heiner Küpper

Overproduction of the poly(ADP‐ribose) polymerase DNA‐binding domain blocks alkylation‐induced DNA repair synthesis in mammalian cells.

M. Molinete, Wim Vermeulen, Alexander Bürkle et al. · The EMBO Journal · 1993 · 245 citations · Full text

Life Sciences, Genetics, Molecular Biology +10

Trans-dominant inhibition of poly(ADP-ribosyl)ation potentiates carcinogen induced gene amplification in SV40-transformed Chinese hamster cells.

Jan-Heiner Küpper, Michael Müller, Alexander Bürkle · PubMed · 1996 · 43 citations

Life Sciences, Genetics, Molecular Biology +17

Overexpression of the DNA-binding domain of poly(ADP-ribose) polymerase inhibits rejoining of ionizing radiation-induced DNA double-strand breaks

Volker Rudat, Nathalie Bachmann, Jan-Heiner Küpper et al. · International Journal of Radiation Biology · 2001 · 32 citations

Life Sciences, Cell Biology, Molecular Biology +17

Overexpression of dominant negative PARP interferes with tumor formation of HeLa cells in nude mice: Evidence for increased tumor cell apoptosis in vivo

Marcus Müller, Mirella L. Meyer‐Ficca, Alexander Bürkle et al. · Oncogene · 1999 · 29 citations

Life Sciences, Molecular Biology, Oncology +14

Poly(ADP-ribose) polymerase activity in intact or permeabilized leukocytes from mammalian species of different longevity

A Bürkle, Marcus Müller, Ivo Wolf et al. · 1994 · 23 citations

Life Sciences, Immunology, Molecular Biology +8