A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance.

Antonio Pizzuti, Lucia Frittitta, A. Argiolas, +9

Diabetes

Insulin receptor expression and function in human breast cancer cell lines.

G Milazzo, Francesco Giorgino, Giuseppe Damante, +5

PubMed

Breast OncologyImmunologyInsulin ReceptorCancer BiologyInsulin Signaling +16

Binding of insulin to isolated nuclei.

I D Goldfine, George J. Smith

Proceedings of the National Academy of Sciences

Molecular PhysiologyGrowth HormoneBiochemistryNative InsulinNatural Sciences +12

Entry of Insulin Into Human Cultured Lymphocytes: Electron Microscope Autoradiographic Analysis

I D Goldfine, A. L. Jones, G. T. Hradek, +2

Science

Insulin SignalingMedicinePhysiologyImmunologyDiabetes +10

Role of Phosphatidylinositol-3-Kinase in Insulin Receptor Signaling: Studies with Inhibitor, LY294002

Víctor Sánchez‐Margalet, I D Goldfine, Chris J. Vlahos, +1

Biochemical and Biophysical Research Communications

Molecular PharmacologyMolecular PhysiologySignal TransductionBiochemistrySignaling Pathway +10

Monoclonal antibodies to the human insulin receptor block insulin binding and inhibit insulin action.

R A Roth, Delanie J. Cassell, Kwok‐Yin Wong, +2

Proceedings of the National Academy of Sciences

ImmunologyInsulin ReceptorImmunotherapyInsulin SignalingMetabolic Syndrome +18

Role of p85 subunit of phosphatidylinositol-3-kinase as an adaptor molecule linking the insulin receptor, p62, and GTPase-activating protein.

Chin K. Sung, Víctor Sánchez‐Margalet, I D Goldfine

Journal of Biological Chemistry

ImmunologyInsulin ReceptorCellular PhysiologyInsulin SignalingSignaling Pathway +19

Monoclonal antibodies to the human insulin receptor that activate glucose transport but not insulin receptor kinase activity.

John Forsayeth, J F, Madhur K. Sinha, +2

Proceedings of the National Academy of Sciences

ImmunologyInsulin ReceptorPancreas TransplantationInsulin SignalingGastrointestinal Peptide Hormone +17

Evidence that insulin plus ATP may induce a conformational change in the beta subunit of the insulin receptor without inducing receptor autophosphorylation.

Betty A. Maddux, I D Goldfine

Journal of Biological Chemistry

Regulation of the insulin receptor by a monoclonal anti-receptor antibody. Evidence that receptor down regulation can be independent of insulin action.

Richard A. Roth, Betty A. Maddux, Delanie J. Cassell, +1

Journal of Biological Chemistry