HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC- Driven Medulloblastoma

Yanxin Pei, Kun-Wei Liu, Jun Wang, +21

Cancer Cell

Myc- Driven MedulloblastomaMalignant DiseaseOncogenic AgentPi3k Antagonists CooperateMedicine +7

F-18 Polyethyleneglycol stilbenes as PET imaging agents targeting Aβ aggregates in the brain

Wei Zhang, Shunichi Oya, Mei‐Ping Kung, +3

Nuclear Medicine and Biology

Neurodegenerative DiseasesAβ AggregatesAlzheimer's DiseaseMedicineImaging Agent +5

F-18 Stilbenes as PET Imaging Agents for Detecting β-Amyloid Plaques in the Brain

Wei Zhang, Shunichi Oya, Mei‐Ping Kung, +3

Journal of Medicinal Chemistry

Stilbene DerivativesImaging Agentβ-Amyloid PlaquesPositron Emission TomographyAlzheimer's Disease +16

Disrupted cortical map and absence of cortical barrels in growth-associated protein (GAP)-43 knockout mice

Donna L. Maier, Shyamala Mani, Stacy L. Donovan, +4

Proceedings of the National Academy of Sciences

EEG-β/γ spectral power elevation in rat: a translatable biomarker elicited by GABA_Aα2/3-positive allosteric modulators at nonsedating anxiolytic doses

Edward P. Christian, Dean H. Snyder, Wei Song, +14

Journal of Neurophysiology

NeurotransmitterNeuromodulation TherapiesNeurophysiological BiomarkersNeurochemical BiomarkersSocial Sciences +22

Ultra-low exposure to alpha-7 nicotinic acetylcholine receptor partial agonists elicits an improvement in cognition that corresponds with an increase in alpha-7 receptor expression in rodents: implications for low dose clinical efficacy

Jennifer L. Werkheiser, S G Sydserff, Stephen J. Hubbs, +7

Neuroscience

NeuropsychologyMedicineNicotinePharmacologyPsychopharmacology +7

[N-methyl-3H3]AZ10419369 Binding to the 5-HT1B Receptor: In Vitro Characterization and in Vivo Receptor Occupancy

Donna L. Maier, Cindy Sobotka-Briner, Min Ding, +7

Journal of Pharmacology and Experimental Therapeutics

Azepines and Piperidines with Dual Norepinephrine Dopamine Uptake Inhibition and Antidepressant Activity

Dean G. Brown, Peter R Bernstein, Ye Wu, +28

ACS Medicinal Chemistry Letters

Psychotropic MedicationPsychopharmacologyAntidepressant ActivityPharmacotherapySocial Sciences +14

Pre-clinical validation of a novel alpha-7 nicotinic receptor radiotracer, [3H]AZ11637326: Target localization, biodistribution and ligand occupancy in the rat brain

Donna L. Maier, Geraldine Hill, Min Ding, +10

Neuropharmacology

Neuro-oncologyTarget LocalizationMedicineNicotineNeuropeptide Receptor +8

2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity

Dean G. Brown, Donna L. Maier, Mark Sylvester, +30

Bioorganic & Medicinal Chemistry Letters

2,6-Disubstituted PyrazinesMolecular PharmacologyRelated AnalogsBiochemistryMedicine +7